SorLA Antibody – Rabbit Polyclonal

SORL1: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Belongs to the VPS10-related sortilin family. SORL1 subfamily.

Protein type: Receptor, misc.; Membrane protein, integral; Cell surface

Cellular Component: cell soma; early endosome; endoplasmic reticulum; endosome; extracellular region; extracellular space; Golgi apparatus; Golgi cisterna; integral to membrane; membrane; multivesicular body; nuclear envelope lumen; perinuclear region of cytoplasm; recycling endosome; trans-Golgi network

Molecular Function: ADP-ribosylation factor binding; beta-amyloid binding; low-density lipoprotein binding; protein binding

Biological Process: cell migration; cholesterol metabolic process; endocytosis; lipid metabolic process; lipid transport; multicellular organismal development; negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of protein binding; negative regulation of protein oligomerization; positive regulation of protein catabolic process; post-Golgi vesicle-mediated transport; protein maturation; protein retention in Golgi; protein targeting; protein targeting to Golgi; protein targeting to lysosome; regulation of smooth muscle cell migration; steroid metabolic process; transport