SPACA3 Antibody – Rabbit Polyclonal

LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family.

Protein type: Hydrolase; Secreted, signal peptide; Endoplasmic reticulum; EC 3.2.1.17; Secreted; Vesicle

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular region; extracellular space

Molecular Function: identical protein binding; lysozyme activity

Biological Process: cellular protein metabolic process; cytolysis; defense response to bacterium; inflammatory response; retinal homeostasis

Disease: Amyloidosis, Familial Visceral