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SREBP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544978

Affinity Purified Sterol regulatory element-binding protein 1 AntibodyTranscriptional activator required for lipid homeostasis. More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SREBP1, Polyclonal Antibody
Full Product Name
SREBP1 Antibody Affinity Purified
Product Gene Name
Product Synonym Names
ADD 1; Class D basic helix-loop-helix protein 1; Processed sterol regulatory element-binding protein 1; SREBF 1; SREBP1; Sterol regulatory element-binding transcription factor 1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.65 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Molecular Weight
45,816 Da
OMIM
184756
3D Structure
ModBase 3D Structure for P36956
Immunogen
Synthetic peptide taken within amino acid region 950-1000 on human Sterol regulatory element binding transcription factor 1 protein.
Expression
liver, adrenal gland, lung, ovary, hepatoma cell lines, kidney, brain, white fat, and muscle.
Molecular Function
Activator
Structure
Belongs to the SREBP family
Subcellular Location
Cytoplasmic vesicle, Endoplasmic Reticulum, Golgi apparatus, Membrane, Nucleus
Applications Tested/Suitable for anti-SREBP1 antibody
ELISA (EIA), IMM, Western Blot (WB)
Application Notes for anti-SREBP1 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500

Other Notes

Small volumes of anti-SREBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SREBP1 purchase

MBS544978 is an antibody targeting SREBP1. Also known as SREBP1 Antibody Affinity Purified. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SREBP1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Sterol regulatory element binding transcription factor 1
NCBI Official Synonym Full Names
sterol regulatory element binding transcription factor 1
NCBI Official Symbol
SREBF1
NCBI Official Synonym Symbols
SREBP1; bHLHd1; SREBP1a; SREBP-1c
UniProt Protein Name
Sterol regulatory element-binding protein 1
UniProt Synonym Protein Names
Class D basic helix-loop-helix protein 1; bHLHd1
UniProt Gene Name
SREBF1
UniProt Synonym Gene Names
BHLHD1; SREBP1; SREBP-1; bHLHd1
UniProt Entry Name
SRBP1_HUMAN
NCBI Protein Information
sterol regulatory element-binding protein 1

NCBI Summary for SREBP1

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016]
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UniProt Comments for SREBP1

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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