Human DEFB4A Active Protein – Cat# MBS546026

Beta-Defensin 2 (DEFB4A) Human Active Protein

Name: DEFB4A Active Protein; Beta-Defensin 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS546026
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546026

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

beta-Defensin 2 (DEFB4A), Active Protein

Full Product Name

Recombinant Human beta-Defensin 2 (rHu BD-2)

Product Gene Name

DEFB4A active protein

Product Synonym Names

beta-Defensin 2; human BD-2; Human beta-Defensin 2

Sequence

GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P

Host

Escherichia coli.

Form/Format

Lyophilized from a 0.2 um filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 130mM NaCl.

Purity/Purification

>98% by SDS-PAGE and HPLC analyses

Preparation and Storage

This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.

Molecular Weight

Approximately 4.3 KDa, a single non-glycosylated polypeptide chain containing 41 amino acids.

Chromosome Location

Chromosome: 8; NC_000008.10 (7752199..7754237). Location: 8p23.1

OMIM

602215

3D Structure

ModBase 3D Structure for O15263

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Fully biologically active when compared to standard. Determined by its ability to chemoattract immature human dendritic cells using a concentration range of 10-100 ng/ml.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Endotoxin

Less than 1EU/ug of rHuBD-2 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.

Other Notes

Small volumes of DEFB4A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DEFB4A purchase

MBS546026 is an active protein targeting DEFB4A. Also known as Recombinant Human beta-Defensin 2 (rHu BD-2). Host: Escherichia coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DEFB4A. It may not necessarily be applicable to this product.

NCBI GI #

3510600

NCBI GeneID

1673

NCBI Accession #

AAC33549.1

UniProt Primary Accession #

O15263

UniProt Secondary Accession #

Q52LC0

UniProt Related Accession #

O15263

NCBI Official Full Name

beta-defensin 2

NCBI Official Synonym Full Names

defensin, beta 4A

NCBI Official Symbol

DEFB4A

NCBI Official Synonym Symbols

BD-2; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102

UniProt Protein Name

Beta-defensin 4A

UniProt Synonym Protein Names

Beta-defensin 2; BD-2; hBD-2; Defensin, beta 2; Skin-antimicrobial peptide 1

Protein Family

Beta-defensin

UniProt Gene Name

DEFB4A

UniProt Synonym Gene Names

DEFB102; DEFB2; DEFB4; BD-2; hBD-2; SAP1

UniProt Entry Name

DFB4A_HUMAN

NCBI Protein Information

beta-defensin 4A; defensin, beta 2; defensin, beta 4; skin-antimicrobial peptide 1

NCBI Summary for DEFB4A

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008]

UniProt Comments for DEFB4A

defensin, beta 2: Has antibacterial activity (Potential). Belongs to the beta-defensin family. LAP/TAP subfamily.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: Golgi lumen; extracellular region

Biological Process: G-protein coupled receptor protein signaling pathway; defense response to bacterium; innate immune response; immune response; chemotaxis

Research Articles on DEFB4A

1. Malassezia furfur modulated IL8 and beta-defensin 2 expression during infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DEFB4A active protein

Reference Product	PubMed Publications
DEFB1 active protein	>119 publications with DEFB4A and DEFB1
CCR6 active protein	>19 publications with DEFB4A and CCR6
IL17A active protein	>14 publications with DEFB4A and IL17A
TLR5 active protein	>7 publications with DEFB4A and TLR5
IL1B active protein	>3 publications with DEFB4A and IL1B
IL1A active protein	>1 publications with DEFB4A and IL1A

Pathways associated with DEFB4A active protein

Products by Pathway	Pathway Diagram
Beta Defensins Pathway antibodies	Beta Defensins Pathway Diagram
Defensins Pathway antibodies	Defensins Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram