Human IL13 Active Protein – Cat# MBS546027

Interleukin-13 (IL13) Human Active Protein

Name: IL13 Active Protein; Interleukin-13; Human; MyBioSource
Brand: MyBioSource
SKU: MBS546027
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546027

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Interleukin-13 (IL13), Active Protein

Full Product Name

Recombinant Human Interleukin-13 (rHu IL-13)

Product Gene Name

IL13 active protein

Product Synonym Names

Interleukin-13; human IL-13; Human Interleukin-13

Sequence

SPGPVPPSTA LRELIEELVN ITQNQKAPLC NGSMVWSINL TAGMYCAALE SLINVSGCSA IEKTQRMLSG FCPHKVSAGQ FSSLHVRDTK IEVAQFVKDL LLHLKKLFRE GRFN

Host

E Coli

Form/Format

Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.

Purity/Purification

>96% by SDS-PAGE and HPLC analyses.

Preparation and Storage

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles

Chromosome Location

Chromosome: 5; NC_000005.9 (131993865..131996801). Location: 5q31

OMIM

147683

3D Structure

ModBase 3D Structure for P35225

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Molecular Weight Note

Approximately 12.5 kDa, a single non-glycosulated polypeptide chain containing 114 amino acids.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 1.0 ng/ml, corresponding to a specific activity of > 1 x 10⁶ units/mg.

Endotoxin Level

Less than 1EU/mg of rHuIL-13 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.

Other Notes

Small volumes of IL13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL13 purchase

MBS546027 is an active protein targeting IL13. Also known as Recombinant Human Interleukin-13 (rHu IL-13). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL13. It may not necessarily be applicable to this product.

NCBI GI #

26787978

NCBI GeneID

3596

NCBI Accession #

NP_002179.2

UniProt Primary Accession #

P35225

UniProt Secondary Accession #

O43644; Q4VB52; Q9UDC7

UniProt Related Accession #

P35225

GenBank Nucleotide #

NM_002188.2

NCBI Official Full Name

interleukin-13

NCBI Official Synonym Full Names

interleukin 13

NCBI Official Symbol

IL13

NCBI Official Synonym Symbols

P600; IL-13

UniProt Protein Name

Interleukin-13

Protein Family

Interleukin

UniProt Gene Name

IL13

UniProt Synonym Gene Names

NC30; IL-13

UniProt Entry Name

IL13_HUMAN

NCBI Protein Information

interleukin-13

NCBI Summary for IL13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

UniProt Comments for IL13

IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function: protein binding; interleukin-13 receptor binding; cytokine activity

Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; microglial cell activation; regulation of proton transport; response to lipopolysaccharide; signal transduction; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; response to ethanol; cell-cell signaling; positive regulation of protein secretion; positive regulation of B cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of NAD(P)H oxidase activity; cell motility; inflammatory response; positive regulation of macrophage activation

Disease: Asthma, Susceptibility To; Allergic Rhinitis

Research Articles on IL13

1. The association of asthma with variation near RAD50/IL13, first discovered in individuals of European ancestry, replicates in individuals of African ancestry.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL13 active protein

Reference Product	PubMed Publications
STAT6 active protein	>385 publications with IL13 and STAT6
IL13RA1 active protein	>287 publications with IL13 and IL13RA1
IL5 active protein	>92 publications with IL13 and IL5
IL18 active protein	>85 publications with IL13 and IL18
GATA3 active protein	>84 publications with IL13 and GATA3
IL4R active protein	>56 publications with IL13 and IL4R
TSLP active protein	>28 publications with IL13 and TSLP
IL13RA2 active protein	>12 publications with IL13 and IL13RA2
VCAM1 active protein	>5 publications with IL13 and VCAM1

Pathways associated with IL13 active protein

Products by Pathway	Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
IL12 Signaling Mediated By STAT4 Pathway antibodies	IL12 Signaling Mediated By STAT4 Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram

Diseases associated with IL13 active protein

Disease Name	Pubmed Publications
Hypersensitivity Antibodies	>1252 publications with IL13 and Hypersensitivity
Inflammation Antibodies	>1185 publications with IL13 and Inflammation
Asthma Antibodies	>1169 publications with IL13 and Asthma
Hypersensitivity, Immediate Antibodies	>1087 publications with IL13 and Hypersensitivity, Immediate
Lung Diseases Antibodies	>1066 publications with IL13 and Lung Diseases
Respiratory Hypersensitivity Antibodies	>904 publications with IL13 and Respiratory Hypersensitivity
Necrosis Antibodies	>574 publications with IL13 and Necrosis
Fibrosis Antibodies	>296 publications with IL13 and Fibrosis
Bronchial Hyperreactivity Antibodies	>213 publications with IL13 and Bronchial Hyperreactivity
Nervous System Diseases Antibodies	>178 publications with IL13 and Nervous System Diseases

Organs/Tissues associated with IL13 active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>162 publications with IL13 and Brain
Bone Marrow Antibodies	>129 publications with IL13 and Bone Marrow
Mixed Antibodies	>66 publications with IL13 and Mixed
Testis Antibodies	>6 publications with IL13 and Testis