Human XCL1 Active Protein – Cat# MBS546033

Lymphotactin (XCL1) Human Active Protein

Name: XCL1 Active Protein; Lymphotactin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS546033
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546033

Lymphotactin is the only known member of the C-chemokine family and signals through the receptor XCR1, formally known as GPR5. The spleen shows the highest level of lymphotactin compared to peripheral leukocytes, lung, colon and small intestine. Lymphotactin… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Lymphotactin (XCL1), Active Protein

Full Product Name

Recombinant Human Lymphotactin (rHu Lymphotactin/XCL1)

Product Gene Name

XCL1 active protein

Product Synonym Names

human Lymphotactin (XCL1); Human Lymphotactin/XCL1

Host

E Coli

Form/Format

Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH7.4, 150mM NaCl
Physical Appearance: Sterile FilteredWhite lyophilized (freeze-dried) powder.

Purity/Purification

>97% by SDS-PAGE and HPLC analyses

Preparation and Storage

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.

Molecular Weight

1137.4

Chromosome Location

Chromosome: 1; NC_000001.10 (168545711..168551315). Location: 1q23

OMIM

600250

3D Structure

ModBase 3D Structure for P47992

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Fully biologically active when compared to standard. Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml.

Endotoxin Level

Less than 1EU/mg of rHuCXCL13 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.

Other Notes

Small volumes of XCL1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XCL1 purchase

MBS546033 is an active protein targeting XCL1. Also known as Recombinant Human Lymphotactin (rHu Lymphotactin/XCL1). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for XCL1. It may not necessarily be applicable to this product.

NCBI GI #

4506853

NCBI GeneID

6375

NCBI Accession #

NP_002986.1

UniProt Primary Accession #

P47992

UniProt Secondary Accession #

Q52MA8

UniProt Related Accession #

P47992

GenBank Nucleotide #

NM_002995.2

NCBI Official Full Name

lymphotactin

NCBI Official Synonym Full Names

chemokine (C motif) ligand 1

NCBI Official Symbol

XCL1

NCBI Official Synonym Symbols

LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a

UniProt Protein Name

Lymphotactin

UniProt Synonym Protein Names

ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1

Protein Family

Lymphotactin

UniProt Gene Name

XCL1

UniProt Synonym Gene Names

LTN; SCYC1

UniProt Entry Name

XCL1_HUMAN

NCBI Protein Information

lymphotactin; SCM-1-alpha; lymphotaxin; cytokine SCM-1; c motif chemokine 1; XC chemokine ligand 1; single cysteine motif 1a; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin)

NCBI Summary for XCL1

This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Nov 2010]

UniProt Comments for XCL1

XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular space; extracellular region

Molecular Function: protein homodimerization activity; chemokine activity; chemokine receptor binding

Biological Process: neutrophil chemotaxis; negative regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; response to virus; negative regulation of transcription factor activity; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; negative regulation of T cell cytokine production; signal transduction; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; release of sequestered calcium ion into cytosol; negative regulation of interferon-gamma production; regulation of inflammatory response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent

Research Articles on XCL1

1. In native annulus fibrosus tissue homeostasis and repair, CXCR3 is evident, whereas XCL1 could not be detected.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with XCL1 active protein

Reference Product	PubMed Publications
CD4 active protein	>43 publications with XCL1 and CD4
XCR1 active protein	>27 publications with XCL1 and XCR1
CXCR3 active protein	>9 publications with XCL1 and CXCR3
CCR5 active protein	>7 publications with XCL1 and CCR5
CCR1 active protein	>5 publications with XCL1 and CCR1
CCR2 active protein	>3 publications with XCL1 and CCR2
CX3CR1 active protein	>3 publications with XCL1 and CX3CR1
CCR3 active protein	>2 publications with XCL1 and CCR3
CCR7 active protein	>2 publications with XCL1 and CCR7

Pathways associated with XCL1 active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram

Diseases associated with XCL1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>27 publications with XCL1 and Inflammation
Disease Models, Animal Antibodies	>16 publications with XCL1 and Disease Models, Animal
Necrosis Antibodies	>15 publications with XCL1 and Necrosis
Neoplasms, Experimental Antibodies	>14 publications with XCL1 and Neoplasms, Experimental
Nervous System Diseases Antibodies	>6 publications with XCL1 and Nervous System Diseases
Drug Hypersensitivity Antibodies	>4 publications with XCL1 and Drug Hypersensitivity
Colonic Neoplasms Antibodies	>4 publications with XCL1 and Colonic Neoplasms
Eye Diseases Antibodies	>4 publications with XCL1 and Eye Diseases
Ovarian Neoplasms Antibodies	>3 publications with XCL1 and Ovarian Neoplasms
Liver Neoplasms Antibodies	>3 publications with XCL1 and Liver Neoplasms

Organs/Tissues associated with XCL1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>134 publications with XCL1 and Blood
Lung Antibodies	>16 publications with XCL1 and Lung
Liver Antibodies	>4 publications with XCL1 and Liver
Prostate Antibodies	>2 publications with XCL1 and Prostate
Connective Tissue Antibodies	>1 publications with XCL1 and Connective Tissue
Uterus Antibodies	>1 publications with XCL1 and Uterus