MCP-4 (CCL13) Active Protein

Name: MCP-4 (CCL13) Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS546049
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546049

CCL13 is a chemoattractant for monocytes and eosinophils, and activates basophils. In addition, it has been reported to be chemotactic for CD4+ and CD8+ T cells, with an activity almost equivalent to that of MCP-3. The bioactivities of CCL13 is most likely… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MCP-4 (CCL13), Active Protein

Full Product Name

Recombinant Human MCP-4 (rHuMCP-4/CCL13)

Product Gene Name

MCP-4 (CCL13) active protein

Product Synonym Names

human MCP-4 (CCL13); Human MCP-4/CCL13

Host

E Coli

Form/Format

Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 130mM NaCl
Physical Appearance: Sterile FilteredWhite lyophilized (freeze-dried) powder.

Purity/Purification

>96% by SDS-PAGE and HPLC analyses

Preparation and Storage

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.

Molecular Weight

10,980 Da

Chromosome Location

Chromosome: 9; NC_006591.3 (38938944..38940231, complement). Location: chromosome: 9

3D Structure

ModBase 3D Structure for Q68Y88

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Molecular Weight Information

8.5 kDa, a single non-glycosylated polypeptide chain containing 77 amino acids.

Biological Activity

Fully biologically active when compared to standard. Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml

Endotoxin Level

Less than 1EU/mg of rHuMCP-4/CCL13 as determined by LAL method

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions

Other Notes

Small volumes of MCP-4 (CCL13) active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCP-4 (CCL13) purchase

MBS546049 is an active protein targeting MCP-4 (CCL13). Also known as Recombinant Human MCP-4 (rHuMCP-4/CCL13). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MCP-4 (CCL13). It may not necessarily be applicable to this product.

NCBI GI #

51371895

NCBI GeneID

445451

NCBI Accession #

BAD36827.1

UniProt Primary Accession #

Q68Y88

UniProt Related Accession #

Q68Y88

NCBI Official Full Name

monocyte chemotactic protein-4

NCBI Official Symbol

CCL13

NCBI Official Synonym Symbols

MCP-4

UniProt Protein Name

C-C motif chemokine 13

UniProt Synonym Protein Names

Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; MCP-4; Small-inducible cytokine A13

UniProt Gene Name

CCL13

UniProt Synonym Gene Names

MCP-4

UniProt Entry Name

CCL13_CANFA

NCBI Protein Information

C-C motif chemokine 13; small-inducible cytokine A13; monocyte chemotactic protein 4; monocyte chemotactic protein-4; monocyte chemoattractant protein 4

UniProt Comments for MCP-4 (CCL13)

Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors

By similarity.

Subcellular location: Secreted

By similarity.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MCP-4 (CCL13) active protein

Reference Product	PubMed Publications
CCR3 active protein	>31 publications with MCP-4 (CCL13) and CCR3
CCR2 active protein	>26 publications with MCP-4 (CCL13) and CCR2
CCR1 active protein	>11 publications with MCP-4 (CCL13) and CCR1
CXCR4 active protein	>8 publications with MCP-4 (CCL13) and CXCR4
CCR7 active protein	>6 publications with MCP-4 (CCL13) and CCR7
CCR6 active protein	>5 publications with MCP-4 (CCL13) and CCR6
CCR10 active protein	>1 publications with MCP-4 (CCL13) and CCR10
CX3CR1 active protein	>1 publications with MCP-4 (CCL13) and CX3CR1

Pathways associated with MCP-4 (CCL13) active protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram

Diseases associated with MCP-4 (CCL13) active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>53 publications with MCP-4 (CCL13) and Inflammation
Liver Diseases Antibodies	>7 publications with MCP-4 (CCL13) and Liver Diseases
Carcinoma Antibodies	>6 publications with MCP-4 (CCL13) and Carcinoma
Hematologic Diseases Antibodies	>5 publications with MCP-4 (CCL13) and Hematologic Diseases
Liver Neoplasms Antibodies	>5 publications with MCP-4 (CCL13) and Liver Neoplasms
Adenocarcinoma Antibodies	>3 publications with MCP-4 (CCL13) and Adenocarcinoma
Neoplasms, Experimental Antibodies	>3 publications with MCP-4 (CCL13) and Neoplasms, Experimental
Muscular Diseases Antibodies	>2 publications with MCP-4 (CCL13) and Muscular Diseases
Kidney Diseases Antibodies	>2 publications with MCP-4 (CCL13) and Kidney Diseases
Hodgkin Disease Antibodies	>2 publications with MCP-4 (CCL13) and Hodgkin Disease