Oncostatin M (209a.a.) (OSM) Active Protein

Name: OSM Active Protein; Oncostatin M (209a.a.); Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS546076
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546076

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSH can exert both stimulatory and inhibitory… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Oncostatin M (209a.a.) (OSM), Active Protein

Full Product Name

RecombinantHuman Oncostatin-M(209a.a.)(rHu OSM 209a.a.)

Product Gene Name

OSM active protein

Product Synonym Names

human Oncostatin M (209a.a.); Human Oncostatin M

Host

E Coli

Form/Format

Lyophilized from a 0.2um filtered concentrated (1.0mg/ml) solution in PBS, pH 7.4.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

>97% by SDS-PAGE and HPLC analyses.

Preparation and Storage

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles

Molecular Weight

28,484 Da

Chromosome Location

Chromosome: 22; NC_000022.10 (30658817..30662829, complement). Location: 22q12.2

OMIM

165095

3D Structure

ModBase 3D Structure for P13725

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Molecular Weight Information

Approximately 23.0-27.0 kDa on a reducing SDS-PAGE.

Biological Activity

Fully biologically active when compared to the standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is < 2 ng/ml, corresponding to a specific activity of > 5x10^5units/mg.

Endotoxin Level

Less than 1EU/ug of rHuOSM(209a.a.) as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.

Other Notes

Small volumes of OSM active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OSM purchase

MBS546076 is an active protein targeting OSM. Also known as RecombinantHuman Oncostatin-M(209a.a.)(rHu OSM 209a.a.). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for OSM. It may not necessarily be applicable to this product.

NCBI GI #

10092621

NCBI GeneID

5008

NCBI Accession #

NP_065391.1

UniProt Primary Accession #

P13725

UniProt Secondary Accession #

Q6FHP8; Q9UCP6

UniProt Related Accession #

P13725

GenBank Nucleotide #

NM_020530.4

NCBI Official Full Name

oncostatin-M preproprotein

NCBI Official Synonym Full Names

oncostatin M

NCBI Official Symbol

OSM

UniProt Protein Name

Oncostatin-M

Protein Family

Oncostatin

UniProt Gene Name

OSM

UniProt Synonym Gene Names

OSM

UniProt Entry Name

ONCM_HUMAN

NCBI Protein Information

oncostatin-M

NCBI Summary for OSM

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

UniProt Comments for OSM

OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity

Biological Process: multicellular organismal development; negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; positive regulation of peptidyl-serine phosphorylation; tyrosine phosphorylation of Stat5 protein; peripheral nervous system development; negative regulation of cell proliferation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; positive regulation of acute inflammatory response; response to heat; positive regulation of cell division; regulation of growth; negative regulation of meiosis; positive regulation of cell proliferation; tyrosine phosphorylation of Stat1 protein; positive regulation of transcription from RNA polymerase II promoter; immune response

Research Articles on OSM

1. Oncostatin M is a FIP1L1/PDGFRA-dependent mediator of cytokine production in chronic eosinophilic leukemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with OSM active protein

Reference Product	PubMed Publications
LIFR active protein	>384 publications with OSM and LIFR
STAT3 active protein	>224 publications with OSM and STAT3
IL6ST active protein	>176 publications with OSM and IL6ST
STAT1 active protein	>74 publications with OSM and STAT1
OSMR active protein	>60 publications with OSM and OSMR
SOCS3 active protein	>27 publications with OSM and SOCS3
VEGFA active protein	>6 publications with OSM and VEGFA
IL3 active protein	>2 publications with OSM and IL3

Pathways associated with OSM active protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with OSM active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>326 publications with OSM and Neoplasms
Inflammation Antibodies	>189 publications with OSM and Inflammation
Necrosis Antibodies	>148 publications with OSM and Necrosis
Disease Models, Animal Antibodies	>64 publications with OSM and Disease Models, Animal
Liver Diseases Antibodies	>64 publications with OSM and Liver Diseases
Brain Diseases Antibodies	>61 publications with OSM and Brain Diseases
Kidney Diseases Antibodies	>52 publications with OSM and Kidney Diseases
Breast Neoplasms Antibodies	>39 publications with OSM and Breast Neoplasms
Carcinoma, Hepatocellular Antibodies	>37 publications with OSM and Carcinoma, Hepatocellular
Lung Diseases Antibodies	>35 publications with OSM and Lung Diseases

Organs/Tissues associated with OSM active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>441 publications with OSM and Blood
Kidney Antibodies	>125 publications with OSM and Kidney
Lung Antibodies	>92 publications with OSM and Lung
Intestine Antibodies	>20 publications with OSM and Intestine
Thymus Antibodies	>17 publications with OSM and Thymus
Ovary Antibodies	>14 publications with OSM and Ovary
Uncharacterized Tissue Antibodies	>2 publications with OSM and Uncharacterized Tissue