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Interleukin-33 (IL33) Murine Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546115

IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related… More details

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Product Overview

Product Name
Interleukin-33 (IL33), Active Protein
Full Product Name
Recombinant Murine Interleukin-33 (rMu IL-33)
Product Gene Name
IL33 active protein
Product Synonym Names
Interleukin-33; murine IL-33; Interleukin-33
Host
E Coli
Form/Format
Lyophilized from a 0.2mm filtered solution in PBS, EDTA and DTT.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder
Purity/Purification
>98% by SDS-PAGE and HPLC analyses
Preparation and Storage
This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.
Molecular Weight
30,759 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (6215149..6257983). Location: 9p24.1
OMIM
608678
3D Structure
ModBase 3D Structure for O95760
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Molecular Weight Information
Approximately 17.3 kDa. The recombinant murine TNF-alpha is a soluble 157 amino acid protein which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is <= 0.5 ng/ml, corresponding to a specific activity of >= 2 x 106units/mg.
Endotoxin Level
Less than 1EU/mg of rmIL-33 as determined by LAL method

Other Notes

Small volumes of IL33 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL33 purchase

MBS546115 is an active protein targeting IL33. Also known as Recombinant Murine Interleukin-33 (rMu IL-33). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL33. It may not necessarily be applicable to this product.

NCBI GI #
15559209
NCBI GeneID
90865
NCBI Accession #
NP_254274.1
UniProt Primary Accession #
O95760
UniProt Secondary Accession #
Q2YEJ5; B4DJ35; B4E1Q9; D3DRI5; E7EAX4
UniProt Related Accession #
O95760
GenBank Nucleotide #
NM_033439.3
NCBI Official Full Name
interleukin-33 isoform 1
NCBI Official Synonym Full Names
interleukin 33
NCBI Official Symbol
IL33
NCBI Official Synonym Symbols
DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; RP11-575C20.2
UniProt Protein Name
Interleukin-33
UniProt Synonym Protein Names
Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules
Protein Family
Interleukin
UniProt Gene Name
IL33
UniProt Synonym Gene Names
C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV
UniProt Entry Name
IL33_HUMAN
NCBI Protein Information
interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules

NCBI Summary for IL33

IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]
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UniProt Comments for IL33

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular space; transport vesicle; chromosome; nucleus

Molecular Function: protein binding; cytokine activity

Biological Process: positive regulation of T-helper 2 type immune response; T-helper 2 type immune response; negative regulation of T-helper 1 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of inflammatory response; positive regulation of macrophage activation
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Research Articles on IL33

1. High serum IL-13 is associated with non- small cell lung cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL33 active protein

 Reference Product  PubMed Publications
 IL1RL1 active protein  >104 publications with IL33 and IL1RL1
 CASP1 active protein  >16 publications with IL33 and CASP1
 IL18 active protein  >15 publications with IL33 and IL18
 TSLP active protein  >10 publications with IL33 and TSLP
 IL25 active protein  >9 publications with IL33 and IL25
 IL18R1 active protein  >5 publications with IL33 and IL18R1
 CSF2 active protein  >1 publications with IL33 and CSF2

Pathways associated with IL33 active protein

 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram

Diseases associated with IL33 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >120 publications with IL33 and Inflammation
 Hypersensitivity, Immediate Antibodies  >59 publications with IL33 and Hypersensitivity, Immediate
 Asthma Antibodies  >59 publications with IL33 and Asthma
 Lung Diseases Antibodies  >54 publications with IL33 and Lung Diseases
 Necrosis Antibodies  >38 publications with IL33 and Necrosis
 Cardiovascular Diseases Antibodies  >28 publications with IL33 and Cardiovascular Diseases
 Neoplasms Antibodies  >17 publications with IL33 and Neoplasms
 Heart Diseases Antibodies  >14 publications with IL33 and Heart Diseases
 Dermatitis, Atopic Antibodies  >13 publications with IL33 and Dermatitis, Atopic
 Nervous System Diseases Antibodies  >10 publications with IL33 and Nervous System Diseases

Organs/Tissues associated with IL33 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >35 publications with IL33 and Lung
 Skin Antibodies  >27 publications with IL33 and Skin
 Heart Antibodies  >22 publications with IL33 and Heart
 Vascular Antibodies  >21 publications with IL33 and Vascular
 Muscle Antibodies  >16 publications with IL33 and Muscle
 Intestine Antibodies  >12 publications with IL33 and Intestine
 Liver Antibodies  >12 publications with IL33 and Liver
 Brain Antibodies  >6 publications with IL33 and Brain
 Eye Antibodies  >6 publications with IL33 and Eye
 Connective Tissue Antibodies  >5 publications with IL33 and Connective Tissue
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