Human CCL11 Active Protein – Cat# MBS546123

Eotaxin (CCL11) Human Active Protein

Name: CCL11 Active Protein; Eotaxin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS546123
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546123

CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Human CCL11 cDNA encodes a 97 amino acid residue precursor protein from which the… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Eotaxin (CCL11), Active Protein

Full Product Name

Recombinant Human Eotaxin (rHu Eotaxin/CCL11)

Product Gene Name

CCL11 active protein

Product Synonym Names

human Eotaxin (CCL11); HumanEotaxin/CCL11

Host

E Coli

Form/Format

Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl
Physical Appearance: Sterile FilteredWhite lyophilized (freeze-dried) powder.

Purity/Purification

>97% by SDS-PAGE and HPLC analyses

Preparation and Storage

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles

Molecular Weight

10,732 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (32612687..32615199). Location: 17q12

OMIM

601156

3D Structure

ModBase 3D Structure for P51671

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Molecular Weight Information

8.1 kDa, a single, non-glycosylated polypeptide chain containing 69 amino acids.

Biological Activity

Fully biologically active when compared to standard. Measured by its ability to chemoattract mouse CCR3 transfected BaF3 mouse pro-B cells.The ED50 for this effect is typically 1-5 ng/mL.

Endotoxin Level

Less than 1EU/mg of rHuEotaxin/CCL11 as determined by LAL method

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.

Other Notes

Small volumes of CCL11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL11 purchase

MBS546123 is an active protein targeting CCL11. Also known as Recombinant Human Eotaxin (rHu Eotaxin/CCL11). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL11. It may not necessarily be applicable to this product.

NCBI GI #

4506827

NCBI GeneID

6356

NCBI Accession #

NP_002977.1

UniProt Primary Accession #

P51671

UniProt Secondary Accession #

P50877; Q92490; Q92491

UniProt Related Accession #

P51671

GenBank Nucleotide #

NM_002986.2

NCBI Official Full Name

eotaxin

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 11

NCBI Official Symbol

CCL11

NCBI Official Synonym Symbols

SCYA11

UniProt Protein Name

Eotaxin

UniProt Synonym Protein Names

C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11

Protein Family

Eotaxin

UniProt Gene Name

CCL11

UniProt Synonym Gene Names

SCYA11

UniProt Entry Name

CCL11_HUMAN

NCBI Protein Information

eotaxin; eotaxin-1; eosinophil chemotactic protein; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)

NCBI Summary for CCL11

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Jul 2013]

UniProt Comments for CCL11

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity

Biological Process: chronic inflammatory response; mast cell chemotaxis; response to virus; actin filament organization; cytoskeleton organization and biogenesis; chemotaxis; signal transduction; protein amino acid phosphorylation; cellular calcium ion homeostasis; regulation of cell shape; positive regulation of angiogenesis; response to radiation; positive regulation of actin filament polymerization; eosinophil chemotaxis; immune response; positive regulation of endothelial cell proliferation; cell adhesion; inflammatory response; positive regulation of cell migration

Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To

Research Articles on CCL11

1. These data uncover a previously unknown role for NRF2 in regulating Eotaxin-1 expression and further the mechanistic understanding of this pathway in modulating inflammatory lung disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL11 active protein

Reference Product	PubMed Publications
CCR3 active protein	>316 publications with CCL11 and CCR3
CXCL10 active protein	>92 publications with CCL11 and CXCL10
CCL17 active protein	>75 publications with CCL11 and CCL17
STAT6 active protein	>56 publications with CCL11 and STAT6
CCL22 active protein	>55 publications with CCL11 and CCL22
CCR5 active protein	>55 publications with CCL11 and CCR5
CCR1 active protein	>45 publications with CCL11 and CCR1
CCR2 active protein	>45 publications with CCL11 and CCR2
CXCR3 active protein	>25 publications with CCL11 and CXCR3
DPP4 active protein	>1 publications with CCL11 and DPP4

Pathways associated with CCL11 active protein

Products by Pathway	Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with CCL11 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>649 publications with CCL11 and Inflammation
Respiratory Tract Diseases Antibodies	>539 publications with CCL11 and Respiratory Tract Diseases
Hypersensitivity Antibodies	>526 publications with CCL11 and Hypersensitivity
Asthma Antibodies	>488 publications with CCL11 and Asthma
Lung Diseases Antibodies	>435 publications with CCL11 and Lung Diseases
Respiratory Hypersensitivity Antibodies	>385 publications with CCL11 and Respiratory Hypersensitivity
Necrosis Antibodies	>181 publications with CCL11 and Necrosis
Bronchial Hyperreactivity Antibodies	>82 publications with CCL11 and Bronchial Hyperreactivity
Drug Hypersensitivity Antibodies	>73 publications with CCL11 and Drug Hypersensitivity
Dermatitis, Atopic Antibodies	>57 publications with CCL11 and Dermatitis, Atopic

Organs/Tissues associated with CCL11 active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>462 publications with CCL11 and Lung
Heart Antibodies	>67 publications with CCL11 and Heart
Intestine Antibodies	>50 publications with CCL11 and Intestine
Uterus Antibodies	>12 publications with CCL11 and Uterus
Kidney Antibodies	>10 publications with CCL11 and Kidney
Stomach Antibodies	>6 publications with CCL11 and Stomach
Pancreas Antibodies	>5 publications with CCL11 and Pancreas
Mammary Gland Antibodies	>3 publications with CCL11 and Mammary Gland
Uncharacterized Tissue Antibodies	>1 publications with CCL11 and Uncharacterized Tissue