Bone Morphogenetic Protein-2 (BMP2) Active Protein

Name: BMP2 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS546125
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546125

BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Bone Morphogenetic Protein-2 (BMP2), Active Protein

Full Product Name

Recombinant Human Bone MorphogeneticProtein-2 (rHu BMP-2)

Product Gene Name

BMP2 active protein

Product Synonym Names

Bone Morphogenetic Protein-2; human BMP-2; Human Bone Morphogenetic Protein 2 (BMP-2)

Host

E Coli

Form/Format

Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution containing 10mM sodium citrate pH 3.5.
Physical Appearance: Sterile FilteredWhite lyophilized (freeze-dried) powder.

Purity/Purification

>95% by SDS-PAGE and HPLC analyses.

Preparation and Storage

Store in room temperature.

Molecular Weight

44,702 Da

Chromosome Location

Chromosome: 20; NC_000020.10 (6748745..6760910). Location: 20p12

OMIM

112261

3D Structure

ModBase 3D Structure for P12643

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Molecular Weight Information

Approximately 23.9 kDa, a single non-glycosylated polypeptide chain containing 209 amino acids.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by the cytolysis of MC3T3-E1 cells is less than 50 ng/ml.

Endotoxin Level

Less than 1EU/mg of rHuBMP-2 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.

Other Notes

Small volumes of BMP2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP2 purchase

MBS546125 is an active protein targeting BMP2. Also known as Recombinant Human Bone MorphogeneticProtein-2 (rHu BMP-2). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP2. It may not necessarily be applicable to this product.

NCBI GI #

4557369

NCBI GeneID

650

NCBI Accession #

NP_001191.1

UniProt Primary Accession #

P12643

UniProt Related Accession #

P12643

GenBank Nucleotide #

NM_001200.2

NCBI Official Full Name

bone morphogenetic protein 2 preproprotein

NCBI Official Synonym Full Names

bone morphogenetic protein 2

NCBI Official Symbol

BMP2

NCBI Official Synonym Symbols

BDA2; BMP2A

UniProt Protein Name

Bone morphogenetic protein 2

UniProt Synonym Protein Names

Bone morphogenetic protein 2A

Protein Family

Bone morphogenetic protein

UniProt Gene Name

BMP2

UniProt Synonym Gene Names

BMP2A; BMP-2; BMP-2A

UniProt Entry Name

BMP2_HUMAN

NCBI Protein Information

bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A

NCBI Summary for BMP2

The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]

UniProt Comments for BMP2

Function: Induces cartilage and bone formation.

Subunit structure: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN

By similarity. Ref.4

Subcellular location: Secreted.

Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Pharmaceutical use: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.

Sequence similarities: Belongs to the TGF-beta family.

Research Articles on BMP2

1. Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BMP2 active protein

Reference Product	PubMed Publications
BMPR2 active protein	>191 publications with BMP2 and BMPR2
BMPR1A active protein	>165 publications with BMP2 and BMPR1A
SMAD4 active protein	>87 publications with BMP2 and SMAD4
BMPR1B active protein	>53 publications with BMP2 and BMPR1B
SMAD7 active protein	>32 publications with BMP2 and SMAD7
NOG active protein	>9 publications with BMP2 and NOG
ACVR2B active protein	>7 publications with BMP2 and ACVR2B
GREM2 active protein	>5 publications with BMP2 and GREM2
CHRD active protein	>3 publications with BMP2 and CHRD
SOSTDC1 active protein	>2 publications with BMP2 and SOSTDC1

Pathways associated with BMP2 active protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
BMP Signalling And Regulation Pathway antibodies	BMP Signalling And Regulation Pathway Diagram
Basal Cell Carcinoma Pathway antibodies	Basal Cell Carcinoma Pathway Diagram
Basal Cell Carcinoma Pathway antibodies	Basal Cell Carcinoma Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Elastic Fibre Formation Pathway antibodies	Elastic Fibre Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Heart Development Pathway antibodies	Heart Development Pathway Diagram

Diseases associated with BMP2 active protein

Disease Name	Pubmed Publications
Bone Diseases Antibodies	>520 publications with BMP2 and Bone Diseases
Neoplasms Antibodies	>264 publications with BMP2 and Neoplasms
Necrosis Antibodies	>99 publications with BMP2 and Necrosis
Inflammation Antibodies	>80 publications with BMP2 and Inflammation
Pain Antibodies	>42 publications with BMP2 and Pain
Hypertrophy Antibodies	>39 publications with BMP2 and Hypertrophy
Hypertension Antibodies	>36 publications with BMP2 and Hypertension
Fibrosis Antibodies	>30 publications with BMP2 and Fibrosis
Breast Neoplasms Antibodies	>29 publications with BMP2 and Breast Neoplasms
Kidney Diseases Antibodies	>24 publications with BMP2 and Kidney Diseases

Organs/Tissues associated with BMP2 active protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>3789 publications with BMP2 and Bone
Connective Tissue Antibodies	>591 publications with BMP2 and Connective Tissue
Embryonic Tissue Antibodies	>423 publications with BMP2 and Embryonic Tissue
Heart Antibodies	>177 publications with BMP2 and Heart
Brain Antibodies	>147 publications with BMP2 and Brain
Kidney Antibodies	>82 publications with BMP2 and Kidney
Lung Antibodies	>66 publications with BMP2 and Lung
Liver Antibodies	>64 publications with BMP2 and Liver
Eye Antibodies	>58 publications with BMP2 and Eye
Prostate Antibodies	>25 publications with BMP2 and Prostate