Glia Maturation Factor Beta (GMFB) Human Protein

Name: GMFB Protein; Glia Maturation Factor Beta; Human; MyBioSource
Brand: MyBioSource
SKU: MBS546147
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546147

GMF-beta, a brain-specific protein that belongs to the actin-binding proteins (ADF) structural family. GMF-beta appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the progression of certain… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Glia Maturation Factor beta (GMFB), Protein

Full Product Name

Recombinant Human Glia Maturation Factor beta (rHu GMF-beta)

Product Gene Name

GMFB protein

Product Synonym Names

Glia Maturation Factor beta ; human GMF-beta; Human GliaMaturation Factor beta; Glia Maturation Factor beta ; human GMF-b; Recombinant Human Glia Maturation Factor beta (rHu GMF-b)

Host

E Coli

Form/Format

Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 130mM NaCl.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

>98% by SDS-PAGE and HPLC analyses.

Preparation and Storage

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.

Molecular Weight

16,713 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (54941202..54955785, complement). Location: 14q22.2

OMIM

601713

3D Structure

ModBase 3D Structure for P60983

Molecular Weight Information

Approximately 16.3 kDa, a single non-glycosylated polypeptide chain containing 145 amino acids.

Endotoxin Level

Less than 1EU/mg of rHuGMF-b as determined by LAL method.

Other Notes

Small volumes of GMFB protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GMFB purchase

MBS546147 is a protein targeting GMFB. Also known as Recombinant Human Glia Maturation Factor beta (rHu GMF-beta). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GMFB. It may not necessarily be applicable to this product.

NCBI GI #

4758442

NCBI GeneID

2764

NCBI Accession #

NP_004115.1

UniProt Primary Accession #

P60983

UniProt Secondary Accession #

P17774; B2R499

UniProt Related Accession #

P60983

GenBank Nucleotide #

NM_004124.2

NCBI Official Full Name

glia maturation factor beta

NCBI Official Synonym Full Names

glia maturation factor, beta

NCBI Official Symbol

GMFB

NCBI Official Synonym Symbols

GMF

UniProt Protein Name

Glia maturation factor beta

Protein Family

Glia maturation factor

UniProt Gene Name

GMFB

UniProt Synonym Gene Names

GMF-beta

UniProt Entry Name

GMFB_HUMAN

NCBI Protein Information

glia maturation factor beta; GMF-beta

UniProt Comments for GMFB

GMF-beta: This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. Belongs to the actin-binding proteins ADF family. GMF subfamily.

Protein type: Inhibitor; Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q22.2

Cellular Component: intracellular

Molecular Function: signal transducer activity; growth factor activity; protein kinase inhibitor activity; enzyme activator activity; actin binding

Biological Process: positive regulation of catalytic activity; nervous system development; negative regulation of protein kinase activity; locomotory behavior; learning; signal transduction; protein amino acid phosphorylation

Research Articles on GMFB

1. The distribution of GMF-immunoreactive cells in and around amyloid plaques and neurofibrillary tangles suggests involvement of GMF in inflammatory responses through reactive glia and a role of GMF in Alzheimer disease pathology.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with GMFB protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with GMFB and Neoplasms
Necrosis Antibodies	>3 publications with GMFB and Necrosis
Nervous System Diseases Antibodies	>2 publications with GMFB and Nervous System Diseases
Immune System Diseases Antibodies	>1 publications with GMFB and Immune System Diseases
Skin Neoplasms Antibodies	>1 publications with GMFB and Skin Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with GMFB and Neoplasms, Experimental
Brain Diseases Antibodies	>1 publications with GMFB and Brain Diseases
Death Antibodies	>1 publications with GMFB and Death
Disease Models, Animal Antibodies	>1 publications with GMFB and Disease Models, Animal

Organs/Tissues associated with GMFB protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>6 publications with GMFB and Brain
Blood Antibodies	>5 publications with GMFB and Blood
Vascular Antibodies	>4 publications with GMFB and Vascular
Thymus Antibodies	>4 publications with GMFB and Thymus
Eye Antibodies	>3 publications with GMFB and Eye
Testis Antibodies	>2 publications with GMFB and Testis
Embryonic Tissue Antibodies	>2 publications with GMFB and Embryonic Tissue
Bone Antibodies	>1 publications with GMFB and Bone
Spinal Cord Antibodies	>1 publications with GMFB and Spinal Cord
Skin Antibodies	>1 publications with GMFB and Skin