TNFSF13B Active Protein – Cat# MBS546213

BAFF (B-Cell Activating Factor) (TNFSF13B) Active Protein

Name: TNFSF13B Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS546213
Price: 205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546213

BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BAFF (B-cell Activating Factor) (TNFSF13B), Active Protein

Full Product Name

Recombinant Human BAFF Receptor (rHu BAFF-R)

Product Gene Name

TNFSF13B active protein

Product Synonym Names

Human BAFF Receptor

Host

E Coli

Form/Format

Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 8.0, 500mM NaCl.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

>95% by reduced SDS-PAGE analyses.

Preparation and Storage

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles

Molecular Weight

31,223 Da

Chromosome Location

Chromosome: 13; NC_000013.10 (108921875..108960832). Location: 13q32-q34

OMIM

603969

3D Structure

ModBase 3D Structure for Q9Y275

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Molecular Weight Information

Approximately 6.0 KDa, a single non-glycosylated polypeptide chain containing 50 amino acids.

Biological Activity

Fully biologically active when compared to standard. Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 1.0-5.0 ug/ml in the presence of 1.0 ug/ml of human soluble BAFF.

Endotoxin Level

Less than 1EU/mg of rHuBAFF-R as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.`

Other Notes

Small volumes of TNFSF13B active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFSF13B purchase

MBS546213 is an active protein targeting TNFSF13B. Also known as Recombinant Human BAFF Receptor (rHu BAFF-R). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFSF13B. It may not necessarily be applicable to this product.

NCBI GI #

4585275

NCBI GeneID

10673

NCBI Accession #

AAD25356.1

UniProt Primary Accession #

Q9Y275

UniProt Secondary Accession #

Q6FHD6; Q7Z5J2; E0ADT7

UniProt Related Accession #

Q9Y275

NCBI Official Full Name

B-cell activating factor

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 13b

NCBI Official Symbol

TNFSF13B

NCBI Official Synonym Symbols

DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 13B

UniProt Synonym Protein Names

B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1

Protein Family

Tumor necrosis factor ligand superfamily

UniProt Gene Name

TNFSF13B

UniProt Synonym Gene Names

BAFF; BLYS; TALL1; TNFSF20; ZTNF4; BLyS; TALL-1

UniProt Entry Name

TN13B_HUMAN

NCBI Protein Information

tumor necrosis factor ligand superfamily member 13B; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20

NCBI Summary for TNFSF13B

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

UniProt Comments for TNFSF13B

BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Apoptosis; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 13q32-q34

Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; integral to membrane; plasma membrane

Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; T cell costimulation; positive regulation of cell proliferation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; immune response; signal transduction

Research Articles on TNFSF13B

1. Serum BAFF levels can be used as a surrogate marker of disease activity in sarcoidosis patients. Increased BAFF may be related to the pathogenesis of sarcoidosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFSF13B active protein

Reference Product	PubMed Publications
TNFRSF13C active protein	>117 publications with TNFSF13B and TNFRSF13C
TNFRSF17 active protein	>95 publications with TNFSF13B and TNFRSF17
TNFRSF13B active protein	>70 publications with TNFSF13B and TNFRSF13B
IL6 active protein	>12 publications with TNFSF13B and IL6
AICDA active protein	>6 publications with TNFSF13B and AICDA
IFNG active protein	>2 publications with TNFSF13B and IFNG

Pathways associated with TNFSF13B active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Spinal Cord Injury Pathway antibodies	Spinal Cord Injury Pathway Diagram

Diseases associated with TNFSF13B active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>426 publications with TNFSF13B and Necrosis
Neoplasms Antibodies	>111 publications with TNFSF13B and Neoplasms
Inflammation Antibodies	>70 publications with TNFSF13B and Inflammation
Nervous System Diseases Antibodies	>46 publications with TNFSF13B and Nervous System Diseases
Kidney Diseases Antibodies	>27 publications with TNFSF13B and Kidney Diseases
Immunologic Deficiency Syndromes Antibodies	>24 publications with TNFSF13B and Immunologic Deficiency Syndromes
Liver Diseases Antibodies	>13 publications with TNFSF13B and Liver Diseases
Thrombocytopenia Antibodies	>11 publications with TNFSF13B and Thrombocytopenia
Hyperplasia Antibodies	>10 publications with TNFSF13B and Hyperplasia
Bone Marrow Diseases Antibodies	>10 publications with TNFSF13B and Bone Marrow Diseases

Organs/Tissues associated with TNFSF13B active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>536 publications with TNFSF13B and Blood
Bone Marrow Antibodies	>55 publications with TNFSF13B and Bone Marrow
Lymph Node Antibodies	>42 publications with TNFSF13B and Lymph Node
Kidney Antibodies	>32 publications with TNFSF13B and Kidney
Skin Antibodies	>14 publications with TNFSF13B and Skin
Liver Antibodies	>13 publications with TNFSF13B and Liver
Brain Antibodies	>12 publications with TNFSF13B and Brain
Vascular Antibodies	>8 publications with TNFSF13B and Vascular
Pharynx Antibodies	>8 publications with TNFSF13B and Pharynx
Thymus Antibodies	>7 publications with TNFSF13B and Thymus