FGF-10 Recombinant Protein

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family.

Protein type: Secreted, signal peptide; Cytokine; Cell development/differentiation; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: cell surface; extracellular matrix; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; chemoattractant activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 2 fibroblast growth factor receptor binding

Biological Process: actin cytoskeleton reorganization; activation of MAPK activity; angiogenesis; blood vessel remodeling; branching morphogenesis of a tube; determination of left/right symmetry; embryonic camera-type eye development; embryonic digestive tract morphogenesis; embryonic genitalia morphogenesis; embryonic pattern specification; epithelial cell proliferation; establishment of mitotic spindle orientation; female genitalia morphogenesis; fibroblast growth factor receptor signaling pathway; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; hair follicle morphogenesis; induction of an organ; induction of positive chemotaxis; keratinocyte proliferation; lacrimal gland development; limb bud formation; male genitalia morphogenesis; MAPKKK cascade; mesonephros development; metanephros development; muscle cell fate commitment; negative regulation of cell differentiation; negative regulation of cell proliferation; odontogenesis of dentine-containing teeth; otic vesicle formation; pancreas development; peptidyl-tyrosine phosphorylation; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; pituitary gland development; positive chemotaxis; positive regulation of ATPase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of keratinocyte migration; positive regulation of lymphocyte proliferation; positive regulation of MAPKKK cascade; positive regulation of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of urothelial cell proliferation; positive regulation of vascular endothelial growth factor receptor signaling pathway; radial glial cell differentiation; regulation of activin receptor signaling pathway; regulation of phosphoinositide 3-kinase cascade; regulation of saliva secretion; regulation of smoothened signaling pathway; response to estradiol stimulus; response to lipopolysaccharide; salivary gland development; smooth muscle cell differentiation; somatic stem cell maintenance; spleen development; thymus development; thyroid gland development; tissue regeneration; urothelial cell proliferation; white fat cell differentiation; wound healing

Disease: Aplasia Of Lacrimal And Salivary Glands; Lacrimoauriculodentodigital Syndrome