Human Interferon-Omega (Rhu IFNW1 Active Protein – Cat# MBS546319

IFN-Omega (IFNW1) Human Interferon-Omega (Rhu Active Protein

Name: IFNW1 Active Protein; IFN-Omega; Human Interferon-Omega (Rhu; MyBioSource
Brand: MyBioSource
SKU: MBS546319
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS546319

Interferon-Omega (IFN-omega) coded by IFNWl gene in human, is a number of the type I interferon family, which includes IFN-alpha, IFN-beta, and IFN-omega. The IFNAR-1/IFNAR-2 receptor complex can help with the signal transduction, followed the antiviral or… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IFN-omega (IFNW1), Active Protein

Full Product Name

Recombinant Human Interferon-Omega (rHuIFN-omega)

Product Gene Name

IFNW1 active protein

Sequence

CDLPQNHGLL SRNTLVLLHQ MRRISPFLCL KDRRDFRFPQ EMVKGSQLQK AHVMSVLH EM LQQIFSLFHT ERSSAAWNMT LLDQLHTGLH QQLQHLETCL LQVVGEGE SA GAISSPALTL RRYFQGIRVY LKEKKYSDCA WEVVRMEIMK SLFLSTNM QE RLRSKDRDLG SS

Form/Format

Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.

Purity/Purification

> 97 % by SDS-PAGE and HPLC analyses

Preparation and Storage

This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably dessicated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C.
Avoid repeated freeze/thaw cycles.

Molecular Weight

Approximately 20.0 kDa, containing 172 amino acid residues with two conserved disulfide bonds

OMIM

147553

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Source

Escherichia coli

Biological Activity

Fully biologically active when compared to standard. The EDso as determined by a chemotaxis bioassay using human TF-l cells is less than 0.01 ng/ml,corresponding to a specific activity of > 1.0 x 10⁸ IU/mg.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder

Endotoxin

Less than 1 EU/ug of rHulFN-omega as determined by LAL method

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20°c. Further dilutions should be made in appropriate buffered solutions.

Other Notes

Small volumes of IFNW1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNW1 purchase

MBS546319 is an active protein targeting IFNW1. Also known as Recombinant Human Interferon-Omega (rHuIFN-omega).

Additional Details

NCBI/Uniprot data below describe general gene information for IFNW1. It may not necessarily be applicable to this product.

NCBI GI #

55275060

NCBI GeneID

3467

NCBI Accession #

AAV49320.1

UniProt Secondary Accession #

Q13168; Q5U802; Q5VWD0; Q7M4P5

UniProt Related Accession #

P05000

NCBI Official Full Name

IFN-omega 1, partial

NCBI Official Synonym Full Names

interferon, omega 1

NCBI Official Symbol

IFNW1

UniProt Protein Name

Interferon omega-1

UniProt Synonym Protein Names

Interferon alpha-II-1

Protein Family

Interferon

UniProt Gene Name

IFNW1

UniProt Entry Name

IFNW1_HUMAN

NCBI Protein Information

interferon omega-1

NCBI Summary for IFNW1

The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. [provided by RefSeq, Nov 2015]

UniProt Comments for IFNW1

IFNW1: Belongs to the alpha/beta interferon family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p22

Cellular Component: extracellular space

Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interferon-alpha/beta receptor binding

Biological Process: adaptive immune response; B cell differentiation; B cell proliferation; cell cycle arrest; cytokine and chemokine mediated signaling pathway; defense response to virus; humoral immune response; innate immune response; natural killer cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein; response to exogenous dsRNA; response to virus; T cell activation during immune response

Research Articles on IFNW1

1. Studies indicate that upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IFNW1 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
RIG-I-like Receptor Signaling Pathway antibodies	RIG-I-like Receptor Signaling Pathway Diagram
RIG-I-like Receptor Signaling Pathway antibodies	RIG-I-like Receptor Signaling Pathway Diagram

Diseases associated with IFNW1 active protein

Disease Name	Pubmed Publications
Skin Neoplasms Antibodies	>1 publications with IFNW1 and Skin Neoplasms
Carcinoma, Squamous Cell Antibodies	>1 publications with IFNW1 and Carcinoma, Squamous Cell
Esophageal Neoplasms Antibodies	>1 publications with IFNW1 and Esophageal Neoplasms
Immune System Diseases Antibodies	>1 publications with IFNW1 and Immune System Diseases

Organs/Tissues associated with IFNW1 active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with IFNW1 and Lung