Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Antibody – Rabbit Polyclonal

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: cell junction; extracellular exosome; extracellular space; integral component of membrane; membrane raft; plasma membrane; platelet alpha granule membrane; secretory granule membrane

Molecular Function: protein binding; protein homodimerization activity

Biological Process: cell recognition; cell-cell adhesion via plasma-membrane adhesion molecules; diapedesis; extracellular matrix organization; glomerular endothelium development; homophilic cell adhesion; leukocyte adhesion; leukocyte migration; neutrophil degranulation; neutrophil extravasation; phagocytosis; platelet degranulation; signal transduction