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Nociceptin (PNOC) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS551065

MBS551065 is an antibody targeting PNOC. Also known as Rabbit anti Nociceptin Polyclonal. Reactive in Human, Mouse, Rat, Rabbit. Host: Rabbit. More details

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Product Overview

Product Name
Nociceptin (PNOC), Polyclonal Antibody
Full Product Name
Rabbit anti Nociceptin Polyclonal
Product Gene Name
Product Synonym Names
Rabbit anti Nociceptin Polyclonal purified; nociceptin; pnoc; polyclonal
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Rabbit
Form/Format
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
Purity/Purification
Serum IgG fraction was purified by Protein G affinity chromatography.
Preparation and Storage
The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
Molecular Weight
20,295 Da
OMIM
601459
3D Structure
ModBase 3D Structure for Q13519
Source Note
Polyclonal Nociceptin (PNOC) antibody was produced from sera of mice immunized with synthetic protein containing Nociceptin antigenic determinants.
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers

Product Categories/Family for anti-PNOC antibody

Applications Tested/Suitable for anti-PNOC antibody
Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)
Application Notes for anti-PNOC antibody
ELISA: Use at a concentration range of 1-2ug/ml.
Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
Immunohistochemical analysis of FFPE rat model of Necrotizing Enterocolitis expressing Nociceptin.

Immunohistochemistry of anti-PNOC antibody

Rabbit Anti-PNOC Polyclonal Antibody – Cat# MBS551065

Other Notes

Small volumes of anti-PNOC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PNOC. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
prepronociceptin preproprotein
UniProt Protein Name
Prepronociceptin
UniProt Synonym Protein Names
Orphanin FQ; PPNOC
Protein Family
UniProt Gene Name
PNOC
UniProt Synonym Gene Names
OFQ
UniProt Entry Name
PNOC_HUMAN

NCBI Summary for PNOC

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]
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UniProt Comments for PNOC

PNOC: Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Belongs to the opioid neuropeptide precursor family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: extracellular region

Molecular Function: neuropeptide hormone activity; protein binding; opioid peptide activity

Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PNOC antibody

 Reference Product  PubMed Publications
 OPRL1 antibody  >4 publications with PNOC and OPRL1
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