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NK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS551080

NK-1, an 11-amino-acid neuropeptide, is released from enteric nerves, sensory neurons, and inflammatory cells of the lamina propria during intestinal inflammation. Conversely, Substance-P activates nerves, epithelial cells, and a variety of immune and… More details

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Product Overview

Product Name
NK1 (Substance-P), Polyclonal Antibody
Full Product Name
Rabbit anti NK1 (Substance-P) Polyclonal
Product Gene Name
anti-NK1 antibody
Product Synonym Gene Name
Neurokinin-1
Product Synonym Names
Rabbit anti Neurokinin-1 Polyclonal purified; nk1; neurokinin-1; neurokinin-a; substance p; nka; polyclonal; PAb; TAC1; neuropeptide
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
Purity/Purification
Serum IgG fraction was purified by Protein G affinity chromatography.
Preparation and Storage
The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
Molecular Weight
15,003 Da
OMIM
162320
3D Structure
ModBase 3D Structure for P20366
Source Note
Polyclonal neurokinin-1 (Substance-P) antibody was produced from sera of rabbits immunized with synthetic protein containing neurokinin-1 antigenic determinants.
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers

Product Categories/Family for anti-NK1 antibody

Polyclonal
Applications Tested/Suitable for anti-NK1 antibody
Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)
Application Notes for anti-NK1 antibody
ELISA: Use at a concentration range of 1-2ug/ml.
Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
Immunohistochemical analysis of Neurokinin-1 expression in FFPE mouse pancreatic islets.
It was used as primary antibody, dilution 1:400.DAB chromogen substrate.
Immunohistochemical analysis of Neurokinin-1 expression in rat colon tissue.
It was used as primary antibody, dilution 1:500, DAB chromogen substrate.

Immunohistochemistry of anti-NK1 antibody

Rabbit Anti-NK1 Polyclonal Antibody – Cat# MBS551080

Other Notes

Small volumes of anti-NK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NK1 purchase

MBS551080 is an antibody targeting NK1. Also known as Rabbit anti NK1 (Substance-P) Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NK1. It may not necessarily be applicable to this product.

NCBI GI #
4507341
NCBI GeneID
6863
NCBI Accession #
NP_003173.1
UniProt Primary Accession #
P20366
UniProt Secondary Accession #
O60600; O60601; Q00072; Q53GH4; Q549V0; Q549V1; Q549V2; Q6FHM1
GenBank Nucleotide #
NM_003182.2
NCBI Official Full Name
protachykinin-1 isoform beta
UniProt Protein Name
Protachykinin-1
UniProt Synonym Protein Names
PPTCleaved into the following 5 chains:Substance PNeurokinin A; NKA; Alternative name(s):; Neuromedin L; Substance K
UniProt Gene Name
TAC1
UniProt Synonym Gene Names
NKA; NKNA; TAC2; NKA; NPK
UniProt Entry Name
TKN1_HUMAN

NCBI Summary for NK1

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
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UniProt Comments for NK1

TAC1: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: extracellular space; cell soma; axon; plasma membrane; extracellular region

Molecular Function: protein binding; substance P receptor binding

Biological Process: positive regulation of synaptic transmission, cholinergic; tachykinin signaling pathway; negative regulation of heart rate; insemination; positive regulation of synaptic transmission, GABAergic; response to hormone stimulus; response to morphine; response to pain; response to lipopolysaccharide; sensory perception of pain; positive regulation of saliva secretion; positive regulation of ossification; synaptic transmission; elevation of cytosolic calcium ion concentration; long-term memory; cell-cell signaling; neuropeptide signaling pathway; positive regulation of lymphocyte proliferation; positive regulation of acute inflammatory response; regulation of blood pressure; positive regulation of stress fiber formation; positive regulation of action potential; inflammatory response; detection of abiotic stimulus; associative learning
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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