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CD112 (PRR2) (CD112) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553012

Nectins are a small family of Ca++independent immunoglobulin (Ig) like cell adhesion molecules (CAMs) that control cell adhesion, proliferation, and migration.Nectin2 is a 60 or 65 kDa type I TM glycoprotein that is found on a variety of cell types. Nectin2… More details

$335 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD112 (PRR2), Active Protein
Full Product Name
Human CD112 Recombinant (PRR2)
Product Gene Name
CD112 active protein
Product Synonym Names
Human CD112 Recombinant (PRR2) ; PVRL2; HVEB; PRR2; CD112; PVRR2; cd-112
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant CD112 is supplied as a 0.2 um filtered PBS solution, pH7.2.
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Preparation and Storage
Recombinant CD112, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.
Molecular Weight
57,742 Da
OMIM
600798
3D Structure
ModBase 3D Structure for Q92692
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
The activity of Recombinant human CD112 was measured in a functional ELISA assay, immobilized recombinant human CD112 at 20 ug/ml (100ul/well) can bind biotinylated DNAM1 with a linear range of 0.08 - 3 ug/ml
Domain
Ig-like C2
Host Note
Optimized DNA sequence encoding Human extracellular domain of human CD112 including a C-terminal 6His tag was expressed in HEK293 cells.
Molecular Weight Note
Recombinant CD112 is a monomer protein consisting of 335 amino acid residue subunits, due to glycosylation migrates as an approximately 48 kDa protein on SDS-PAGE.

Product Categories/Family for CD112 active protein

Receptors CD

Other Notes

Small volumes of CD112 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD112 purchase

MBS553012 is an active protein targeting CD112. Also known as Human CD112 Recombinant (PRR2). Host: HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for CD112. It may not necessarily be applicable to this product.

NCBI GI #
112789532
NCBI GeneID
5819
NCBI Accession #
NP_001036189.1
UniProt Primary Accession #
Q92692
UniProt Secondary Accession #
O75455; Q6IBI6; Q96J29
UniProt Related Accession #
Q7Z456; Q7Z457; Q7Z458; Q92692; Q9UEI6
GenBank Nucleotide #
NM_001042724.1
NCBI Official Full Name
poliovirus receptor-related protein 2 isoform delta
UniProt Protein Name
Poliovirus receptor-related protein 2
UniProt Synonym Protein Names
Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin-2
UniProt Gene Name
PVRL2
UniProt Synonym Gene Names
HVEB; PRR2; Herpesvirus entry mediator B; HveB
UniProt Entry Name
PVRL2_HUMAN

NCBI Summary for CD112

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD112

nectin 2: Probable cell adhesion protein. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cell surface; focal adhesion; plasma membrane; integral to membrane; intercellular junction; zonula adherens

Molecular Function: viral receptor activity; identical protein binding; protein binding; protein homodimerization activity; coreceptor activity; cell adhesion molecule binding

Biological Process: acrosome formation; establishment of mitochondrion localization; intercellular junction assembly and maintenance; regulation of immune response; sperm mitochondrion organization and biogenesis; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; spermatid nuclear differentiation; cytoskeleton organization and biogenesis; susceptibility to natural killer cell mediated cytotoxicity; virion attachment, binding of host cell surface coreceptor; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; positive regulation of mast cell activation; fertilization; viral envelope fusion with host membrane; cell part morphogenesis; adhesion to host; homophilic cell adhesion; spermatid development
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD112 active protein

 Reference Product  PubMed Publications
 PVRL3 active protein  >3 publications with CD112 and PVRL3

Pathways associated with CD112 active protein

 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with CD112 active protein

 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >4 publications with CD112 and Craniofacial Abnormalities
 Neoplasms Antibodies  >2 publications with CD112 and Neoplasms
 Neurodegenerative Diseases Antibodies  >2 publications with CD112 and Neurodegenerative Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with CD112 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with CD112 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with CD112 and Liver Neoplasms
 Lymphoma Antibodies  >1 publications with CD112 and Lymphoma

Organs/Tissues associated with CD112 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with CD112 and Blood
 Brain Antibodies  >2 publications with CD112 and Brain
 Liver Antibodies  >1 publications with CD112 and Liver
 Heart Antibodies  >1 publications with CD112 and Heart
 Testis Antibodies  >1 publications with CD112 and Testis
 Lung Antibodies  >1 publications with CD112 and Lung
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