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Bone Morphogenetic Protein-2 (BMP-2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553031

MBS553031 is a recombinant protein targeting BMP-2. Also known as Human Bone Morphogenetic protein-2 Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders). More details

$240 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Bone Morphogenetic protein-2 (BMP-2), Recombinant Protein
Full Product Name
Human Bone Morphogenetic protein-2 Recombinant
Product Gene Name
BMP-2 recombinant protein
Product Synonym Names
bmp2; bone morphogenetic protein; bmp-2
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for 1 year from date of receipt at -20° C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
OMIM
112261
3D Structure
ModBase 3D Structure for P12643
Source Note
Optimized DNA sequence encoding Human Bone Morphogenetic Protein-2 mature chain was expressed in Escherichia Coli.
Molecular Weight Note
Native human Bone Morphogenetic Protein-2 is generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 13 kDa. Recombinant BMP-2 is a disulfide-linked homodimeric protein consisting of two 115 amino acid residue subunits.BMP2 migrates as an approximately 25 kDa protein under non-reducing conditions and as a 13 kDa protein under reducing conditions in SDS-PAGE.
Biological Activity
The ED(50) was determined by its ability to induce alkaline phosphatase production by C2C12 myogenic cells cells was found to be less than 50 ng/ml
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Presentation
Recombinant Human Bone Morphogenetic Protein-2 was lyophilized from a 0.2 um filtered solution in 20mM AcOH pH 6.5.
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Product Categories/Family for BMP-2 recombinant protein

Cytokines

Other Notes

Small volumes of BMP-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP-2. It may not necessarily be applicable to this product.

NCBI GI #
4557369
NCBI GeneID
650
NCBI Accession #
NP_001191.1
UniProt Primary Accession #
P12643
UniProt Related Accession #
P12643
GenBank Nucleotide #
NM_001200.2
NCBI Official Full Name
bone morphogenetic protein 2 preproprotein
UniProt Protein Name
Bone morphogenetic protein 2
UniProt Synonym Protein Names
Bone morphogenetic protein 2A
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP2
UniProt Synonym Gene Names
BMP2A; BMP-2; BMP-2A
UniProt Entry Name
BMP2_HUMAN

NCBI Summary for BMP-2

The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]

UniProt Comments for BMP-2

Function: Induces cartilage and bone formation.

Subunit structure: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN

By similarity. Ref.4

Subcellular location: Secreted.

Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Pharmaceutical use: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.

Sequence similarities: Belongs to the TGF-beta family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BMP-2 recombinant protein

 Reference Product  PubMed Publications
 TGFB1 recombinant protein  >191 publications with BMP-2 and TGFB1
 BMPR2 recombinant protein  >175 publications with BMP-2 and BMPR2
 BMPR1A recombinant protein  >150 publications with BMP-2 and BMPR1A
 BMPR1B recombinant protein  >46 publications with BMP-2 and BMPR1B
 MGP recombinant protein  >28 publications with BMP-2 and MGP
 COL2A1 recombinant protein  >25 publications with BMP-2 and COL2A1
 TGFB2 recombinant protein  >21 publications with BMP-2 and TGFB2
 ACVR1 recombinant protein  >17 publications with BMP-2 and ACVR1
 ASCL1 recombinant protein  >11 publications with BMP-2 and ASCL1
 NOG recombinant protein  >9 publications with BMP-2 and NOG

Pathways associated with BMP-2 recombinant protein

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram

Diseases associated with BMP-2 recombinant protein

 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >423 publications with BMP-2 and Bone Diseases
 Neoplasms Antibodies  >210 publications with BMP-2 and Neoplasms
 Osteoporosis Antibodies  >111 publications with BMP-2 and Osteoporosis
 Congenital Abnormalities Antibodies  >81 publications with BMP-2 and Congenital Abnormalities
 Inflammation Antibodies  >58 publications with BMP-2 and Inflammation
 Craniofacial Abnormalities Antibodies  >37 publications with BMP-2 and Craniofacial Abnormalities
 Lung Diseases Antibodies  >34 publications with BMP-2 and Lung Diseases
 Hypertension Antibodies  >33 publications with BMP-2 and Hypertension
 Leukemia Antibodies  >33 publications with BMP-2 and Leukemia
 Pain Antibodies  >31 publications with BMP-2 and Pain

Organs/Tissues associated with BMP-2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3094 publications with BMP-2 and Bone
 Connective Tissue Antibodies  >477 publications with BMP-2 and Connective Tissue
 Embryonic Tissue Antibodies  >367 publications with BMP-2 and Embryonic Tissue
 Heart Antibodies  >134 publications with BMP-2 and Heart
 Brain Antibodies  >131 publications with BMP-2 and Brain
 Kidney Antibodies  >58 publications with BMP-2 and Kidney
 Lung Antibodies  >51 publications with BMP-2 and Lung
 Liver Antibodies  >47 publications with BMP-2 and Liver
 Eye Antibodies  >45 publications with BMP-2 and Eye
 Prostate Antibodies  >24 publications with BMP-2 and Prostate
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