Human BMP-3 Recombinant Protein – Cat# MBS553054

Bone Morphogenetic Protein-3b (BMP-3) Human Recombinant Protein

Name: BMP-3 Recombinant Protein; Bone Morphogenetic Protein-3b; Human; MyBioSource
Brand: MyBioSource
SKU: MBS553054
Price: 190 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553054

BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Bone Morphogenetic Protein-3b (BMP-3), Recombinant Protein

Full Product Name

Human Bone Morphogenetic Protein-3b Recombinant

Product Gene Name

BMP-3 recombinant protein

Product Synonym Names

Human Bone Morphogenetic Protein-3 Recombinant; bmp3; bmp-3; Bone Morphogenetic Protein

Sequence

MAHVPARTSP GPGPQLLLLL LPLFLLLLRD VAGSHRAPAW SALPAAADGL QGDRDLQRHP GDAAATLGPS AQDMVAVHMH RLYEKYSRQG ARPGGGNTVR SFRARLEVVD QKAVYFFNLT SMQDSEMILT ATFHFYSEPP RWPRALEVLC KPRAKNASGR PLPLGPPTRQ HLLFRSLSQN TATQGLLRGA MALAPPPRGL WQAKDISPIV KAARRDGELL LSAQLDSEER DPGVPRPSPY APYILVYAND LAISEPNSVA VTLQRYDPFP AGDPEPRAAP NNSADPRVRR AAQATGPLQD NELPGLDERP PRAHAQHFHK HQLWPSPFRA LKPRPGRKDR RKKGQEVFMA ASQVLDFDEK TMQKARRKQW DEPRVCSRRY LKVDFADIGW NEWIISPKSF DAYYCAGACE FPMPKIVRPS NHATIQSIVR AVGIIPGIPE PCCVPDKMNS LGVLFLDENR NVVLKVYPNM SVDTCACR

Host

E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)

Form/Format

Recombinant BMP-3b was lyophilized from a 0.2 um filtered 1mg/ml 10 mM sodium citrate (pH 3.5) containing 10% glycerol.

Purity/Purification

>95%, as determined by SDS-PAGE and HPLC

Preparation and Storage

Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months.

Avoid repeated freeze/thaw cycles.

Molecular Weight

53,122 Da

OMIM

601361

3D Structure

ModBase 3D Structure for P55107

Domain

TGFB

Host Note

Optimized DNA sequence encoding Human Bone Morphogenetic Protein-3b mature chain was expressed in Escherichia Coli.

Endotoxin

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).

Reconstitution

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Molecular Weight Note

Native human Bone Morphogenetic Protein-3b is generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 13 kDa.

Recombinant BMP-3b is a disulfide-linked monomer protein consisting of 111 amino acid residue subunits. BMP3 migrates as an approximately 12-13 kDa protein under reducing conditions in SDS-PAGE.

Product Categories/Family for BMP-3 recombinant protein

Cytokines

Other Notes

Small volumes of BMP-3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP-3 purchase

MBS553054 is a recombinant protein targeting BMP-3. Also known as Human Bone Morphogenetic Protein-3b Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for BMP-3. It may not necessarily be applicable to this product.

NCBI GI #

4826740

NCBI GeneID

2662

NCBI Accession #

NP_004953.1

UniProt Primary Accession #

P55107

UniProt Secondary Accession #

Q5VSQ8; Q9UCX6

UniProt Related Accession #

P55107; Q8N6T2

GenBank Nucleotide #

NM_004962.3

NCBI Official Full Name

bone morphogenetic protein 3B

UniProt Protein Name

Bone morphogenetic protein 3B

UniProt Synonym Protein Names

Bone-inducing protein; BIP; Growth/differentiation factor 10

Protein Family

Growth/differentiation factor

UniProt Gene Name

GDF10

UniProt Synonym Gene Names

BMP3B; BMP-3B; BIP; GDF-10

UniProt Entry Name

BMP3B_HUMAN

NCBI Summary for BMP-3

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. [provided by RefSeq, Jul 2008]

UniProt Comments for BMP-3

GDF10: is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that plays a role in skeletal morphogenesis. [provided by RefSeq, Jul 2008]

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; fat cell differentiation; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; skeletal development; cell development; growth

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with BMP-3 recombinant protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram

Diseases associated with BMP-3 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>6 publications with BMP-3 and Neoplasms
Lung Neoplasms Antibodies	>2 publications with BMP-3 and Lung Neoplasms
Bone Resorption Antibodies	>2 publications with BMP-3 and Bone Resorption
Lung Diseases Antibodies	>2 publications with BMP-3 and Lung Diseases
Demyelinating Diseases Antibodies	>1 publications with BMP-3 and Demyelinating Diseases
Genital Neoplasms, Female Antibodies	>1 publications with BMP-3 and Genital Neoplasms, Female
Brain Injuries Antibodies	>1 publications with BMP-3 and Brain Injuries
Uterine Diseases Antibodies	>1 publications with BMP-3 and Uterine Diseases
Endocrine Gland Neoplasms Antibodies	>1 publications with BMP-3 and Endocrine Gland Neoplasms
Adenocarcinoma Antibodies	>1 publications with BMP-3 and Adenocarcinoma

Organs/Tissues associated with BMP-3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>6 publications with BMP-3 and Brain
Embryonic Tissue Antibodies	>5 publications with BMP-3 and Embryonic Tissue
Lung Antibodies	>5 publications with BMP-3 and Lung
Connective Tissue Antibodies	>4 publications with BMP-3 and Connective Tissue
Testis Antibodies	>2 publications with BMP-3 and Testis
Pineal Gland Antibodies	>1 publications with BMP-3 and Pineal Gland
Prostate Antibodies	>1 publications with BMP-3 and Prostate
Ear Antibodies	>1 publications with BMP-3 and Ear