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Fibroblast Growth Factor 21 (FGF-21) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553064

MBS553064 is a recombinant protein targeting FGF-21. Also known as Human Fibroblast Growth Factor 21 Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders). More details

$240 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fibroblast Growth Factor 21 (FGF-21), Recombinant Protein
Full Product Name
Human Fibroblast Growth Factor 21 Recombinant
Product Gene Name
FGF-21 recombinant protein
Product Synonym Names
FGF21; fgf-21; fibroblast growth factor; kgf2; kgf-2
Sequence
LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR FLCQRPDGAL YGSLHFDPEA CSFRELLLED GYNVYQSEAH GLPLHLPGNK SPHRDPAPRG PARFLPLPGL PPALPEPPGI LAPQPPDVGS SDPLSMVGPS QGRSPSYAS
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant FGF21 was lyophilized from 0.2 um filtered PBS solution, pH 7.0.
Purity/Purification
>96%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
22,300 Da
OMIM
609436
3D Structure
ModBase 3D Structure for Q9NSA1
Domain
HBGF/IL1
Host Note
Optimized DNA sequence encoding Human Fibroblast Growth Factor-21 mature chain was expressed in Escherichia Coli.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight Note
Native human FGF21 is generated by the proteolytic removal of the signal peptide
and propeptide, this molecule has a calculated molecular mass of approximately 20kDa.

Recombinant Fibroblast Growth Factor 21 is a disulfide-linked monomer protein consisting of 182 amino acid residue subunits, and migrates as an approximately 20kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Product Categories/Family for FGF-21 recombinant protein

Cytokines

Other Notes

Small volumes of FGF-21 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF-21. It may not necessarily be applicable to this product.

NCBI GI #
9506597
NCBI GeneID
26291
NCBI Accession #
NP_061986.1
UniProt Primary Accession #
Q9NSA1
UniProt Secondary Accession #
Q8N683
UniProt Related Accession #
Q9NSA1
GenBank Nucleotide #
NM_019113.2
NCBI Official Full Name
fibroblast growth factor 21
UniProt Protein Name
Fibroblast growth factor 21
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF21
UniProt Synonym Gene Names
FGF-21
UniProt Entry Name
FGF21_HUMAN

NCBI Summary for FGF-21

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for FGF-21

FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular region

Molecular Function: protein binding; growth factor activity; fibroblast growth factor receptor binding

Biological Process: positive regulation of glucose import; cell-cell signaling; positive regulation of cell proliferation; positive regulation of low-density lipoprotein receptor biosynthetic process; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF-21 recombinant protein

 Reference Product  PubMed Publications
 KLB recombinant protein  >7 publications with FGF-21 and KLB

Pathways associated with FGF-21 recombinant protein

 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with FGF-21 recombinant protein

 Disease Name  Pubmed Publications
 Obesity Antibodies  >43 publications with FGF-21 and Obesity
 Fatty Liver Antibodies  >40 publications with FGF-21 and Fatty Liver
 Insulin Resistance Antibodies  >38 publications with FGF-21 and Insulin Resistance
 Liver Diseases Antibodies  >25 publications with FGF-21 and Liver Diseases
 Diabetes Mellitus, Type 2 Antibodies  >19 publications with FGF-21 and Diabetes Mellitus, Type 2
 Hyperglycemia Antibodies  >12 publications with FGF-21 and Hyperglycemia
 Acidosis Antibodies  >9 publications with FGF-21 and Acidosis
 Neoplasms Antibodies  >8 publications with FGF-21 and Neoplasms
 Inflammation Antibodies  >8 publications with FGF-21 and Inflammation
 Kidney Diseases Antibodies  >7 publications with FGF-21 and Kidney Diseases
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