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EXODUS-2 Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553133

Exodus-2, which is a member of the family of CC- Chemokines, has a unique 36 (murine) or 37 (human) amino acid carboxyl-terminal extension not seen in other chemokines. Exodus-2 selectively stimulates the chemotaxis of adult T-lymphocytes and is expressed… More details

$240 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Exodus-2, Recombinant Protein
Full Product Name
Human Exodus-2 Recombinant
Product Gene Name
Exodus-2 recombinant protein
Product Synonym Names
Exodus-2; Exodus2; ccl21
Sequence
MAQSLALSLL ILVLAFGIPR TQGSDGGAQD CCLKYSQRKI PAKVVRSYRK QEPSLGCSIP AILFLPRKRS QAELCADPKE LWVQQLMQHL DKTPSPQKPA QGCRKDRGAS KTGKKGKGSK GCKRTERSQT PKGP
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant Exodus-2 was lyophilized from a 0.2 um filtered solution in 2.5% glycine, 0.5% sucrose, 0.01% Tween80, 5 mM Glutamic acid, pH 4.5.
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
14,646 Da
OMIM
602737
3D Structure
ModBase 3D Structure for O00585
Domain
IL8
Host Note
Optimized DNA sequence encoding Human Exodus-2 mature chain was expressed in Escherichia Coli.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight Note
Native human Exodus-2 is generated by the proteolytic removal of the signal peptide
and propeptide, this molecule has a calculated molecular mass of approximately 12 kDa.

Recombinant Exodus-2 is a disulfide-linked homodimeric protein consisting of 112 amino acid residue subunits, and migrates as an approximately 12 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Product Categories/Family for Exodus-2 recombinant protein

Cytokines

Other Notes

Small volumes of Exodus-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Exodus-2 purchase

MBS553133 is a recombinant protein targeting Exodus-2. Also known as Human Exodus-2 Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for Exodus-2. It may not necessarily be applicable to this product.

NCBI GI #
4506835
NCBI GeneID
6366
NCBI Accession #
NP_002980.1
UniProt Primary Accession #
O00585
UniProt Related Accession #
O00585; Q5VZ73; Q6ICR7
GenBank Nucleotide #
NM_002989.2
NCBI Official Full Name
C-C motif chemokine 21
UniProt Protein Name
C-C motif chemokine 21
UniProt Synonym Protein Names
6Ckine; Beta-chemokine exodus-2; Secondary lymphoid-tissue chemokine; SLC; Small-inducible cytokine A21
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL21
UniProt Synonym Gene Names
SCYA21; SLC
UniProt Entry Name
CCL21_HUMAN

NCBI Summary for Exodus-2

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]
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UniProt Comments for Exodus-2

CCL21: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine receptor binding; chemokine activity; CCR7 chemokine receptor binding

Biological Process: positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; formation of immunological synapse; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of JNK cascade; positive regulation of cell adhesion mediated by integrin; positive regulation of receptor-mediated endocytosis; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; positive regulation of pseudopodium formation; cell-cell signaling; positive regulation of actin filament polymerization; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; ruffle organization and biogenesis; dendritic cell chemotaxis; establishment of T cell polarity; immune response; inflammatory response; positive regulation of cell-matrix adhesion
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Exodus-2 recombinant protein

 Reference Product  PubMed Publications
 CCR7 recombinant protein  >352 publications with Exodus-2 and CCR7
 CXCL13 recombinant protein  >97 publications with Exodus-2 and CXCL13
 CCRL1 recombinant protein  >3 publications with Exodus-2 and CCRL1
 VCAN recombinant protein  >1 publications with Exodus-2 and VCAN
 CCBP2 recombinant protein  >1 publications with Exodus-2 and CCBP2

Pathways associated with Exodus-2 recombinant protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with Exodus-2 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >132 publications with Exodus-2 and Inflammation
 Skin Diseases Antibodies  >61 publications with Exodus-2 and Skin Diseases
 Arthritis, Rheumatoid Antibodies  >41 publications with Exodus-2 and Arthritis, Rheumatoid
 Vascular Diseases Antibodies  >32 publications with Exodus-2 and Vascular Diseases
 Liver Diseases Antibodies  >22 publications with Exodus-2 and Liver Diseases
 Breast Neoplasms Antibodies  >21 publications with Exodus-2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >21 publications with Exodus-2 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >17 publications with Exodus-2 and Lung Neoplasms
 Diabetes Mellitus Antibodies  >15 publications with Exodus-2 and Diabetes Mellitus
 Fibrosis Antibodies  >11 publications with Exodus-2 and Fibrosis

Organs/Tissues associated with Exodus-2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >302 publications with Exodus-2 and Lymph Node
 Vascular Antibodies  >108 publications with Exodus-2 and Vascular
 Spleen Antibodies  >84 publications with Exodus-2 and Spleen
 Lung Antibodies  >67 publications with Exodus-2 and Lung
 Liver Antibodies  >42 publications with Exodus-2 and Liver
 Embryonic Tissue Antibodies  >25 publications with Exodus-2 and Embryonic Tissue
 Pancreas Antibodies  >20 publications with Exodus-2 and Pancreas
 Kidney Antibodies  >19 publications with Exodus-2 and Kidney
 Muscle Antibodies  >17 publications with Exodus-2 and Muscle
 Intestine Antibodies  >17 publications with Exodus-2 and Intestine
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