Cytomegalovirus Pp28 (UL99) (CMV pp28) Cytomegalovirus Recombinant Protein

Function: Tegument protein that may play a role in the nucleocapsid secondary envelopment at the trans-Golgi network during virus morphogenesis

Potential. Ref.5 Ref.6

Subunit structure: Interacts with capsid-binding protein UL94

By similarity.

Subcellular location: Virion tegument

By similarity. Virion membrane; Lipid-anchor

By similarity. Host cell membrane; Lipid-anchor; Cytoplasmic side

By similarity. Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side

Potential. Host nucleus membrane

By similarity. Note: Virion membrane-associated tegument protein. Associates with host membrane lipids rafts

By similarity. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN)

By similarity. Ref.6

Domain: The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL94 (HHV-1 UL16 homolog)

By similarity.

Post-translational modification: Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging

By similarity.Phosphorylated. Packaging is selective for underphosphorylated forms

By similarity. Ref.1

Sequence similarities: Belongs to the herpesviridae HHV-1 UL11 family.