EBV EBNA1 Recombinant Protein – Cat# MBS553169

Epstein-Barr Virus EBNA1 (EBV EBNA1) Recombinant Protein

Name: EBV EBNA1 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS553169
Price: 995 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553169

EBNA1 is the only EBV protein consistently expressed in all proliferating infected cells and plays several important roles in EBV latent infection, including the initiation of EBV DNA replication, the mitotic segregation of the EBV genomes, and… More details

$995 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Epstein-Barr Virus EBNA1 (EBV EBNA1), Recombinant Protein

Full Product Name

Epstein-Barr Virus EBNA1 Recombinant

Product Gene Name

EBV EBNA1 recombinant protein

Product Synonym Names

ebna1; ebna-1; ebv; epstein barr

Host

N/A (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)

Form/Format

0.2 um filtered 50mM Tris-HCI pH 8, 10mM glutathione, 60mM NaCI, 0.25% Sarkosyl and 50% Glycerol.

Purity/Purification

>90%

Concentration

Bradford test: 7.14 mg/mL (lot specific)

Preparation and Storage

This protein can be stored in working aliquots at 2-8°C for one month, or at -20°C for six months without detectable loss of activity.
Avoid repeated freeze/thaw cycles.

Molecular Weight

Tested on SDS-PAGE: 45 kDa

3D Structure

ModBase 3D Structure for P03211

Host Note

DNA sequence encoding fragment of EBV EBNA1 was expressed in Escherichia Coli.

Product Categories/Family for EBV EBNA1 recombinant protein

Viral Antigens

Applications Tested/Suitable for EBV EBNA1 recombinant protein

Suitable for use in ELISA and WB applications. Final concentrations to be determined by end user.

Other Notes

Small volumes of EBV EBNA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EBV EBNA1 purchase

MBS553169 is a recombinant protein targeting EBV EBNA1. Also known as Epstein-Barr Virus EBNA1 Recombinant. Host: N/A (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for EBV EBNA1. It may not necessarily be applicable to this product.

NCBI GI #

82503233

NCBI GeneID

3783774

NCBI Accession #

YP_401677.1

UniProt Primary Accession #

P03211

UniProt Secondary Accession #

Q777E1

UniProt Related Accession #

QQBE31

GenBank Nucleotide #

NC_007605.1

NCBI Official Full Name

EBNA-1

UniProt Protein Name

Epstein-Barr nuclear antigen 1

UniProt Gene Name

EBNA1

UniProt Synonym Gene Names

EBNA-1

UniProt Entry Name

EBNA1_EBVB9

UniProt Comments for EBV EBNA1

Function: Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival. Ref.8

Subunit structure: Interacts with human USP7. Interacts with human EBP2; this interaction is important for the stable segregation of EBV episomes during cell division but not for the replication of the episomes. Interacts with BGLF4; this interaction facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function. Ref.4 Ref.5 Ref.6 Ref.8

Subcellular location: Host nucleus Ref.3.

Sequence similarities: Belongs to the herpesviridae EBNA1 family.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.