• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GRO-Beta (CXCL2) (GRO-beta) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553193

Growth regulated oncogene- gamma belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity) and the new designation is CXCL3. This factor is known mainly because of its chemotactic… More details

$240 / 0.002 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRO-beta (CXCL2), Recombinant Protein
Full Product Name
Human GRO-beta (CXCL2) Recombinant
Product Gene Name
GRO-beta recombinant protein
Product Synonym Names
GRO-beta; GROg; cxcl2; mip2; mip-2
Sequence
MARATLSAAP SNPRLLRVAL LLLLLVAASR RAAGAPLATE LRCQCLQTLQ GIHLKNIQSV KVKSPGPHCA QTEVIATLKN GQKACLNPAS PMVKKIIEKM LKNGKSN
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant GRO-beta/CXCL2 was lyophilized from a 0.2um filtered concentrated (1mg/ml) solution in 20mM Tris, pH 8.0.
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
11,389 Da
OMIM
139110
3D Structure
ModBase 3D Structure for P19875
Domain
IL8
Host Note
Optimized DNA sequence encoding Human GRO-beta CXCL2 mature chain was expressed in Escherichia Coli.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers
Molecular Weight Note
Native human GRO-beta is generated by the proteolytic removal of the signal peptide and propeptide. The molecule has a calculated molecular mass of approximately 8 kDa.

Recombinant GRO-beta is a disulfide-linked homodimeric protein consisting of 74 amino acid residue subunits, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Product Categories/Family for GRO-beta recombinant protein

Cytokines

Other Notes

Small volumes of GRO-beta recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRO-beta purchase

MBS553193 is a recombinant protein targeting GRO-beta. Also known as Human GRO-beta (CXCL2) Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for GRO-beta. It may not necessarily be applicable to this product.

NCBI GI #
4504155
NCBI GeneID
2920
NCBI Accession #
NP_002080.1
UniProt Primary Accession #
P19875
UniProt Secondary Accession #
Q6FGD6; Q9UPB8
UniProt Related Accession #
P19875; Q6LD33
GenBank Nucleotide #
NM_002089.3
NCBI Official Full Name
C-X-C motif chemokine 2
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alphaCleaved into the following chain:GRO-beta(5-73); Alternative name(s):; GRO-beta-T; Hematopoietic synergistic factor; HSF; SB-251353
UniProt Gene Name
CXCL2
UniProt Synonym Gene Names
GRO2; GROB; MIP2A; SCYB2; Gro-beta; MIP2-alpha; HSF
UniProt Entry Name
CXCL2_HUMAN

NCBI Summary for GRO-beta

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
Show more

UniProt Comments for GRO-beta

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; immune response; chemotaxis; inflammatory response; regulation of cell proliferation
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRO-beta recombinant protein

 Reference Product  PubMed Publications
 CXCR2 recombinant protein  >112 publications with GRO-beta and CXCR2
 CXCR1 recombinant protein  >17 publications with GRO-beta and CXCR1

Pathways associated with GRO-beta recombinant protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with GRO-beta recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >720 publications with GRO-beta and Inflammation
 Lung Diseases Antibodies  >299 publications with GRO-beta and Lung Diseases
 Lung Injury Antibodies  >212 publications with GRO-beta and Lung Injury
 Pneumonia Antibodies  >141 publications with GRO-beta and Pneumonia
 Cardiovascular Diseases Antibodies  >119 publications with GRO-beta and Cardiovascular Diseases
 Vascular Diseases Antibodies  >116 publications with GRO-beta and Vascular Diseases
 Acute Lung Injury Antibodies  >110 publications with GRO-beta and Acute Lung Injury
 Drug Toxicity Antibodies  >108 publications with GRO-beta and Drug Toxicity
 Sepsis Antibodies  >99 publications with GRO-beta and Sepsis
 Neoplasms Antibodies  >70 publications with GRO-beta and Neoplasms

Organs/Tissues associated with GRO-beta recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >802 publications with GRO-beta and Blood
 Lung Antibodies  >494 publications with GRO-beta and Lung
 Liver Antibodies  >146 publications with GRO-beta and Liver
 Bone Antibodies  >98 publications with GRO-beta and Bone
 Bone Marrow Antibodies  >87 publications with GRO-beta and Bone Marrow
 Brain Antibodies  >85 publications with GRO-beta and Brain
 Intestine Antibodies  >78 publications with GRO-beta and Intestine
 Kidney Antibodies  >74 publications with GRO-beta and Kidney
 Eye Antibodies  >43 publications with GRO-beta and Eye
 Lymph Node Antibodies  >30 publications with GRO-beta and Lymph Node
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000