Human GRO-gamma Recombinant Protein – Cat# MBS553210

GRO-Gamma (CXCL3) (GRO-gamma) Human Recombinant Protein

Name: GRO-gamma Recombinant Protein; GRO-Gamma (CXCL3); Human; MyBioSource
Brand: MyBioSource
SKU: MBS553210
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553210

Growth regulated oncogene- gamma belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity) and the new designation is CXCL3. This factor is known mainly because of its chemotactic… More details

$240 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRO-gamma (CXCL3), Recombinant Protein

Full Product Name

Human GRO-gamma (CXCL3) Recombinant

Product Gene Name

GRO-gamma recombinant protein

Product Synonym Names

GRO-gamma; GROg; cxcl3; mip2; mip-2

Sequence

MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ GIHLKNIQSV NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI LNKGSTN

Host

E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)

Form/Format

Recombinant GRO-gamma/CXCL3 was lyophilized from a 0.2um filtered concentrated (1mg/ml) solution in 40mM NaCl, 10mM PB, pH 7.0.

Purity/Purification

>95%, as determined by SDS-PAGE and HPLC

Preparation and Storage

The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

Molecular Weight

11,342 Da

OMIM

139111

3D Structure

ModBase 3D Structure for P19876

Domain

IL8

Host Note

Optimized DNA sequence encoding Human GRO-gamma mature chain was expressed in Escherichia Coli

Endotoxin

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).

Reconstitution

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers

Molecular Weight Note

Native human GRO-gamma is generated by the proteolytic removal of the signal peptide and propeptide. The molecule has a calculated molecular mass of approximately 8 kDa.

Recombinant GRO-gamma is a disulfide-linked homodimeric protein consisting of 74 amino acid residue subunits, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Product Categories/Family for GRO-gamma recombinant protein

Cytokines

Other Notes

Small volumes of GRO-gamma recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRO-gamma purchase

MBS553210 is a recombinant protein targeting GRO-gamma. Also known as Human GRO-gamma (CXCL3) Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for GRO-gamma. It may not necessarily be applicable to this product.

NCBI GI #

54144650

NCBI GeneID

2921

NCBI Accession #

NP_002081.2

UniProt Primary Accession #

P19876

UniProt Secondary Accession #

Q4W5H9

UniProt Related Accession #

P19876; Q6LD32

GenBank Nucleotide #

NM_002090.2

NCBI Official Full Name

C-X-C motif chemokine 3

UniProt Protein Name

C-X-C motif chemokine 3

UniProt Synonym Protein Names

GRO-gamma(1-73); Growth-regulated protein gamma; GRO-gamma; Macrophage inflammatory protein 2-beta

UniProt Gene Name

CXCL3

UniProt Synonym Gene Names

GRO3; GROG; SCYB3; GRO-gamma; MIP2-beta

UniProt Entry Name

CXCL3_HUMAN

NCBI Summary for GRO-gamma

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

UniProt Comments for GRO-gamma

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; inflammatory response; regulation of cell proliferation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRO-gamma recombinant protein

Reference Product	PubMed Publications
CXCR2 recombinant protein	>6 publications with GRO-gamma and CXCR2
CXCR1 recombinant protein	>5 publications with GRO-gamma and CXCR1

Pathways associated with GRO-gamma recombinant protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with GRO-gamma recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>45 publications with GRO-gamma and Inflammation
Neoplasms Antibodies	>20 publications with GRO-gamma and Neoplasms
Lung Diseases Antibodies	>9 publications with GRO-gamma and Lung Diseases
Adenocarcinoma Antibodies	>7 publications with GRO-gamma and Adenocarcinoma
Drug Toxicity Antibodies	>5 publications with GRO-gamma and Drug Toxicity
Melanoma Antibodies	>5 publications with GRO-gamma and Melanoma
Vascular Diseases Antibodies	>4 publications with GRO-gamma and Vascular Diseases
Colonic Neoplasms Antibodies	>4 publications with GRO-gamma and Colonic Neoplasms
Neoplasm Metastasis Antibodies	>4 publications with GRO-gamma and Neoplasm Metastasis
Colorectal Neoplasms Antibodies	>4 publications with GRO-gamma and Colorectal Neoplasms

Organs/Tissues associated with GRO-gamma recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>40 publications with GRO-gamma and Blood
Lung Antibodies	>10 publications with GRO-gamma and Lung
Intestine Antibodies	>6 publications with GRO-gamma and Intestine
Embryonic Tissue Antibodies	>3 publications with GRO-gamma and Embryonic Tissue
Uterus Antibodies	>2 publications with GRO-gamma and Uterus
Brain Antibodies	>2 publications with GRO-gamma and Brain
Liver Antibodies	>2 publications with GRO-gamma and Liver
Pancreas Antibodies	>1 publications with GRO-gamma and Pancreas