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TARC (CCL17) (TARC) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553219

Thymus and activation- regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T cells that… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TARC (CCL17), Recombinant Protein
Full Product Name
Human TARC (CCL17) Recombinant
Product Gene Name
TARC recombinant protein
Product Synonym Names
ccl-17 ; CCL17; tarc
Sequence
MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant TARC was lyophilized from a 0.2 um filtered 20mM PB,100mM NaCl solution pH 7.5.
Purity/Purification
>98%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
10,507 Da
OMIM
601520
3D Structure
ModBase 3D Structure for Q92583
Domain
IL8
Host Note
Optimized DNA sequence encoding Human TARC (CCL17) mature chain was expressed in Escherichia Coli.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight Note
Human CCL-17, generated by the proteolytic removal of the signal peptide
and propeptide and has a calculated molecular mass of approximately 8kDa.

Recombinant TARC is a disulfide-linked monomeric protein consisting of 72 amino acid residue subunits and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.

Product Categories/Family for TARC recombinant protein

Cytokines

Other Notes

Small volumes of TARC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TARC purchase

MBS553219 is a recombinant protein targeting TARC. Also known as Human TARC (CCL17) Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for TARC. It may not necessarily be applicable to this product.

NCBI GI #
4506829
NCBI GeneID
6361
NCBI Accession #
NP_002978.1
UniProt Primary Accession #
Q92583
UniProt Secondary Accession #
Q2M287; A0N0Q9
UniProt Related Accession #
Q92583
GenBank Nucleotide #
NM_002987.2
NCBI Official Full Name
C-C motif chemokine 17
UniProt Protein Name
C-C motif chemokine 17
UniProt Synonym Protein Names
CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine
UniProt Gene Name
CCL17
UniProt Synonym Gene Names
SCYA17; TARC
UniProt Entry Name
CCL17_HUMAN

NCBI Summary for TARC

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]
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UniProt Comments for TARC

CCL17: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR4 chemokine receptor binding; chemokine activity; receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; multicellular organismal development; immune response; chemotaxis; negative regulation of myoblast differentiation; inflammatory response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TARC recombinant protein

 Reference Product  PubMed Publications
 CCR4 recombinant protein  >194 publications with TARC and CCR4
 CCR8 recombinant protein  >31 publications with TARC and CCR8

Pathways associated with TARC recombinant protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with TARC recombinant protein

 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >206 publications with TARC and Hypersensitivity
 Inflammation Antibodies  >189 publications with TARC and Inflammation
 Respiratory Tract Diseases Antibodies  >140 publications with TARC and Respiratory Tract Diseases
 Lung Diseases Antibodies  >116 publications with TARC and Lung Diseases
 Dermatitis, Atopic Antibodies  >113 publications with TARC and Dermatitis, Atopic
 Asthma Antibodies  >93 publications with TARC and Asthma
 Respiratory Hypersensitivity Antibodies  >89 publications with TARC and Respiratory Hypersensitivity
 Neoplasms Antibodies  >72 publications with TARC and Neoplasms
 Eosinophilia Antibodies  >45 publications with TARC and Eosinophilia
 Dermatitis, Contact Antibodies  >24 publications with TARC and Dermatitis, Contact
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