• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Interleukin-24 (IL-24) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553230

IL-24 (melanoma differentiation-associated gene-7 (mda-7)), a member of the IL-10 cytokine family, possesses the properties of a classical cytokine as well as tumor suppressor effects. The exact role of IL-24 in the immune system has not been defined but… More details

$240 / 0.002 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-24 (IL-24), Recombinant Protein
Full Product Name
Human Interleukin-24 Recombinant
Product Gene Name
IL-24 recombinant protein
Product Synonym Names
MDA7; ST16; il24; interleukin-24; il-24
Sequence
MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ GQEFHFGPCQ VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV SDAESCYLVH TLLEFYLKTV FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ LQPSQENEMF SIRDSAHRRF LLFRRAFKQL DVEAALTKAL GEVDILLTWM QKFYKL
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant Interleukin-24 was lyophilized from 0.2um filtered solution in PBS, pH 7.4 including 5% (w/v) trehalose.
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Preparation and Storage
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
23,825 Da
OMIM
604136
3D Structure
ModBase 3D Structure for Q13007
Domain
4 Helix Cytokine
Host Note
Optimized DNA sequence encoding Human Interleukin-24 mature chain including a C-terminal His tag was expressed in HEK293 cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight Note
Native human IL-24 has a calculated molecular mass of approximately 18.5 kDa.

Recombinant IL-24 is a disulfide-linked monomeric protein consisting of 165 amino acid residue subunits, and migrates as an approximately 35kDa protein due to glycosylation under reducing conditions in SDS-PAGE.

Product Categories/Family for IL-24 recombinant protein

Cytokines

Other Notes

Small volumes of IL-24 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-24 purchase

MBS553230 is a recombinant protein targeting IL-24. Also known as Human Interleukin-24 Recombinant. Host: HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for IL-24. It may not necessarily be applicable to this product.

NCBI GI #
297632401
NCBI GeneID
11009
NCBI Accession #
NP_001172085.1
UniProt Primary Accession #
Q13007
UniProt Secondary Accession #
Q2YHE5; Q53XZ7; Q5YLN8; Q96DB0; Q96KG4
UniProt Related Accession #
Q13007; Q2YHE5; Q2YHE6; Q53XZ7; Q5YLN8
GenBank Nucleotide #
NM_001185156.1
NCBI Official Full Name
interleukin-24 isoform 3
UniProt Protein Name
Interleukin-24
UniProt Synonym Protein Names
Melanoma differentiation-associated gene 7 protein; MDA-7; Suppression of tumorigenicity 16 protein
Protein Family
Interleukin
UniProt Gene Name
IL24
UniProt Synonym Gene Names
MDA7; ST16; IL-24; MDA-7
UniProt Entry Name
IL24_HUMAN

NCBI Summary for IL-24

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for IL-24

IL24: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. Belongs to the IL-10 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; endoplasmic reticulum

Molecular Function: cytokine activity

Biological Process: negative regulation of cell proliferation; wound healing; apoptosis; positive regulation of cell proliferation; positive regulation of JAK-STAT cascade; positive regulation of caspase activity; immune response; negative regulation of caspase activity; inflammatory response; negative regulation of cell migration; positive regulation of tyrosine phosphorylation of Stat3 protein; serine phosphorylation of STAT3 protein
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL-24 recombinant protein

 Reference Product  PubMed Publications
 IL20RA recombinant protein  >1 publications with IL-24 and IL20RA

Pathways associated with IL-24 recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram

Diseases associated with IL-24 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >24 publications with IL-24 and Neoplasms
 Melanoma Antibodies  >14 publications with IL-24 and Melanoma
 Carcinoma Antibodies  >10 publications with IL-24 and Carcinoma
 Liver Diseases Antibodies  >5 publications with IL-24 and Liver Diseases
 Lung Neoplasms Antibodies  >5 publications with IL-24 and Lung Neoplasms
 Death Antibodies  >5 publications with IL-24 and Death
 Lung Diseases Antibodies  >5 publications with IL-24 and Lung Diseases
 Inflammation Antibodies  >4 publications with IL-24 and Inflammation
 Liver Neoplasms Antibodies  >4 publications with IL-24 and Liver Neoplasms
 Drug Toxicity Antibodies  >3 publications with IL-24 and Drug Toxicity

Organs/Tissues associated with IL-24 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with IL-24 and Blood
 Lung Antibodies  >5 publications with IL-24 and Lung
 Vascular Antibodies  >3 publications with IL-24 and Vascular
 Prostate Antibodies  >2 publications with IL-24 and Prostate
 Spleen Antibodies  >2 publications with IL-24 and Spleen
 Bone Antibodies  >1 publications with IL-24 and Bone
 Mouth Antibodies  >1 publications with IL-24 and Mouth
 Brain Antibodies  >1 publications with IL-24 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000