• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Il-17ra (CD217) Fc Tagged (IL17RA) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553248

IL-17 is a potent regulator of the neutrophil response. Both IL-17A and IL-17F are capable of signaling through IL-17RA to induce granulopoietic factors such as G-CSF and stem cell factor which leads to expansion of neutrophil progenitors in the bone marrow… More details

$335 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-17RA (CD217) Fc tagged (IL17RA), Recombinant Protein
Full Product Name
Human IL-17RA (CD217) Fc tagged Recombinant
Product Gene Name
IL17RA recombinant protein
Product Synonym Gene Name
IL-17R
Product Synonym Names
Human IL-17 receptor Fc tag Recombinant; il-17ra; il17RA; interleukin-17 r
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Species Reactivity
Measured by its ability to bind immobilized recombinant human IL-17A at a concentration range of 1-32ng/ml in a functional ELISA assay.
Form/Format
Recombinant Interleukin-17 receptor alpha is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
Purity/Purification
>98%, as determined by SDS-PAGE and HPLC
Preparation and Storage
Recombinant IL-17 receptor alpha, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.
Molecular Weight
96,122 Da
OMIM
605461
3D Structure
ModBase 3D Structure for Q96F46
Host Note
Optimized DNA sequence encoding extracellular domain of human IL17R receptor including a C terminal Human IgG1 Fc tag was expressed in HEK293 cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Recombinant IL17RA/Fc is a homodimer protein consisting of 300 amino acid residue subunits, due to glycosylation migrates as an approximately 55kD protein under reducing SDS-PAGE conditions.

Product Categories/Family for IL17RA recombinant protein

Receptors CD

Other Notes

Small volumes of IL17RA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17RA purchase

MBS553248 is a recombinant protein targeting IL17RA. Also known as Human IL-17RA (CD217) Fc tagged Recombinant. Reactive in Measured by its ability to bind immobilized recombinant human IL-17A at a concentration range of 1-32ng/ml in a functional ELISA assay.. Host: HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for IL17RA. It may not necessarily be applicable to this product.

NCBI GI #
23238208
NCBI GeneID
23765
NCBI Accession #
NP_055154.3
UniProt Primary Accession #
Q96F46
UniProt Secondary Accession #
O43844; Q20WK1
GenBank Nucleotide #
NM_014339.6
NCBI Official Full Name
interleukin-17 receptor A
UniProt Protein Name
Interleukin-17 receptor A
UniProt Synonym Protein Names
CDw217
Protein Family
Interleukin-17 receptor
UniProt Gene Name
IL17RA
UniProt Synonym Gene Names
IL17R; IL-17 receptor A; IL-17RA
UniProt Entry Name
I17RA_HUMAN

NCBI Summary for IL17RA

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
Show more

UniProt Comments for IL17RA

IL17RA: Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Widely expressed.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q11.1

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: protein binding; interleukin-17 receptor activity

Biological Process: cell surface receptor linked signal transduction; positive regulation of interleukin-23 production; cytokine and chemokine mediated signaling pathway

Disease: Candidiasis, Familial, 5
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000