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Interleukin-18 Binding Protein (Il-18bp) (IL18BP) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553250

IL-18BP is a secreted protein that binds IL-18 with high affinity and prevents its interaction with the IL-18R. Different isoforms of IL-18BP have been demonstrated, four in human and two in the murine system, and biological activity is limited to particular… More details

$335 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Interleukin-18 Binding Protein (IL-18BP) (IL18BP), Recombinant Protein
Full Product Name
Human Interleukin-18 Binding Protein (IL-18BP) Recombinant
Product Gene Name
IL18BP recombinant protein
Product Synonym Gene Name
IL-18
Product Synonym Names
Human IL-18 Binding Protein Recombinant; il18bp; IL18; il-18bp
Sequence
MTMRHNWTPD LSPLWVLLLC AHVVTLLVRA TPVSQTTTAA TASVRSTKDP CPSQPPVFPA AKQCPALEVT WPEVEVPLNG TLSLSCVACS RFPNFSILYW LGNGSFIEHL PGRLWEGSTS RERGSTGTQL CKALVLEQLT PALHSTNFSC VLVDPEQVVQ RHVVLAQLWA GLRATLPPTQ EALPSSHSSP QQQG
Host
HEK Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant IL-18BP is supplied as an 0.2 um filtered PBS solution.
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Preparation and Storage
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
21,099 Da
OMIM
604113
3D Structure
ModBase 3D Structure for O95998
Domain
Ig Like C2
Host Note
Optimized DNA sequence encoding Human Interleukin-18 Binding Protein (IL-18BP) mature chain fused to an C-terminal polyHis tag was expressed in HEK cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Native human IL-18BP, generated by the proteolytic removal of the signal peptide and propeptide,the molecule has a calculated molecular mass of approximately 19 kDa. Recombinant Interleukin-18 Binding Protein is a disulfide-linked monomer protein consisting of 164 amino acid residue subunits fused to a polyHis tag, migrates due to glycosylation as an approximately as a 45kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Product Categories/Family for IL18BP recombinant protein

Cytokines

Other Notes

Small volumes of IL18BP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL18BP purchase

MBS553250 is a recombinant protein targeting IL18BP. Also known as Human Interleukin-18 Binding Protein (IL-18BP) Recombinant. Host: HEK Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for IL18BP. It may not necessarily be applicable to this product.

NCBI GI #
89111125
NCBI GeneID
10068
NCBI Accession #
NP_001034748.1
UniProt Primary Accession #
O95998
UniProt Secondary Accession #
O95993; O96027; Q9NZA9; Q9UBR7; B3KUZ0; B7WPK4
GenBank Nucleotide #
NM_001039659.1
NCBI Official Full Name
interleukin-18-binding protein isoform a
UniProt Protein Name
Interleukin-18-binding protein
UniProt Synonym Protein Names
Tadekinig-alfa
Protein Family
Interleukin-18-binding protein
UniProt Gene Name
IL18BP
UniProt Synonym Gene Names
IL-18BP
UniProt Entry Name
I18BP_HUMAN

NCBI Summary for IL18BP

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
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UniProt Comments for IL18BP

IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; extracellular region

Molecular Function: receptor antagonist activity; interleukin-18 binding

Biological Process: T-helper 1 type immune response; response to lipopolysaccharide
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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