• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Il-1 Receptor Type II (Cd121b) (IL1R2) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553257

Two distinct IL-lRs have been identified, termed type I and type II. The type I IL-lR is an 80-kDa glycoprotein found predominantly on T cells and fibroblasts, whereas the type II IL-lR is a 60- to 65-kDa molecule that is expressed on activated T cells, B… More details

$335 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-1 receptor type II (CD121b) (IL1R2), Recombinant Protein
Full Product Name
Rat IL-1 receptor type II Recombinant (CD121b)
Product Gene Name
IL1R2 recombinant protein
Product Synonym Gene Name
IL-1R2
Product Synonym Names
Rat IL-1 receptor type II Recombinant ; CD121B; D2S1473; IL-1R2; IL-1RB; IL1R2; IL1RB; P80; IL1R2
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant Rat IL-1 receptor II (CD121b) is lyophilized from 0.2 um filtered PBS solution, pH7.2, 5% Trehalose.
Purity/Purification
>97%, as determined by SDS-PAGE and HPLC
Preparation and Storage
Recombinant Rat IL1R2 can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.
Molecular Weight
46,353 Da
3D Structure
ModBase 3D Structure for P43303
Domain
Ig-like C2
Host Note
Optimized DNA sequence encoding Rat extracellular domain of Rat IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells.
Molecular Weight Note
Recombinant rat IL-R2 (CD121b) is a protein consisting of 353 amino acid residue subunits, due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE.

Product Categories/Family for IL1R2 recombinant protein

Receptors CD

Other Notes

Small volumes of IL1R2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL1R2 purchase

MBS553257 is a recombinant protein targeting IL1R2. Also known as Rat IL-1 receptor type II Recombinant (CD121b). Host: HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for IL1R2. It may not necessarily be applicable to this product.

NCBI GI #
16758836
NCBI GeneID
117022
NCBI Accession #
NP_446405.1
UniProt Primary Accession #
P43303
UniProt Secondary Accession #
Q5BJ99
GenBank Nucleotide #
NM_053953.1
NCBI Official Full Name
interleukin-1 receptor type 2
UniProt Protein Name
Interleukin-1 receptor type 2
UniProt Synonym Protein Names
CD121 antigen-like family member B; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II
Protein Family
Interleukin-1 receptor
UniProt Gene Name
Il1r2
UniProt Synonym Gene Names
Il-1r2; Il1rb; IL-1R-2; IL-1RT-2; IL-1RT2; IL-1R-beta; mIL-1R2; mIL-1RII; sIL-1R2; sIL-1RII
UniProt Entry Name
IL1R2_RAT

NCBI Summary for IL1R2

receptor for IL-1 alpha and IL-1 beta [RGD, Feb 2006]

UniProt Comments for IL1R2

Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

By similarity.

Subunit structure: Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein. Cell membrane

By similarity. Secreted

By similarity.

Post-translational modification: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase

By similarity.

Sequence similarities: Belongs to the interleukin-1 receptor family.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000