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Epiregulin (EREG) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553271

Epiregulin, an epidermal growth factor family member, acts as a local signal mediator and shows dual biological activity, stimulating the proliferation of fibroblasts, hepatocytes, smooth muscle cells, and keratinocytes while inhibiting the growth of several… More details

$240 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Epiregulin (EREG), Recombinant Protein
Full Product Name
Human Epiregulin Recombinant
Product Gene Name
EREG recombinant protein
Product Synonym Gene Name
Epiregulin
Product Synonym Names
epiregulin; ereg; egf
Sequence
MTAGRRMEML CAGRVPALLL CLGFHLLQAV LSTTVIPSCI PGESSDNCTA LVQTEDNPRV AQVSITKCSS DMNGYCLHGQ CIYLVDMSQN YCRCEVGYTG VRCEHFFLTV HQPLSKEYVA LTVILIILFL ITVVGSTYYF CRWYRNRKSK EPKKEYERVT SGDPELPQV
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Human Epiregulin was lyophilized from a 0.2 um filtered solution in PBS pH 7.5.
Purity/Purification
>97%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
19,044 Da
OMIM
602061
3D Structure
ModBase 3D Structure for O14944
Domain
EGF
Host Note
Optimized DNA sequence encoding Human Epiregulin mature chain was expressed in Escherichia Coli.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers
Molecular Weight Note
Recombinant Human Epiregulin, generated by the proteolytic removal of the signal peptide and propeptide, is a disulfide-linked monomer protein.

Recombinant Human Epiregulin consists of 50 amino acids and migrates as an approximately 6 kDa protein under reducing conditions.

Product Categories/Family for EREG recombinant protein

Cytokines

Other Notes

Small volumes of EREG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EREG purchase

MBS553271 is a recombinant protein targeting EREG. Also known as Human Epiregulin Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for EREG. It may not necessarily be applicable to this product.

NCBI GI #
4557567
NCBI GeneID
2069
NCBI Accession #
NP_001423.1
UniProt Primary Accession #
O14944
UniProt Secondary Accession #
Q6FH69; B2RC66
GenBank Nucleotide #
NM_001432.2
NCBI Official Full Name
proepiregulin preproprotein
UniProt Protein Name
Proepiregulin
Protein Family
Proepiregulin
UniProt Gene Name
EREG
UniProt Synonym Gene Names
EPR
UniProt Entry Name
EREG_HUMAN

NCBI Summary for EREG

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]
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UniProt Comments for EREG

Epiregulin: Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; integral to plasma membrane; extracellular region

Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding

Biological Process: response to peptide hormone stimulus; wound healing; nerve growth factor receptor signaling pathway; activation of MAPK activity; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-6 biosynthetic process; female meiosis; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; primary follicle stage, oogenesis; positive regulation of epidermal growth factor receptor activity; cell-cell signaling; positive regulation of cell proliferation; positive regulation of innate immune response; ovarian cumulus expansion; angiogenesis; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; positive regulation of cytokine production; anatomical structure morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of cytokine biosynthetic process; keratinocyte proliferation; luteinizing hormone signaling pathway; oocyte maturation; ovulation; keratinocyte differentiation; organ morphogenesis; positive regulation of protein kinase activity; mRNA transcription; innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of phosphorylation; positive regulation of DNA replication
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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