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Il-31r Beta (Osmrb) (IL31R) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553291

Two types of functional hOSM receptors are known: the type I OSM receptor is identical to the LIF receptor that consists of gp130 and the LIF receptor β subunit (LIFRβ), and the type II OSM receptor consists of gp130 and the OSM receptor β subunit (OSMRβ). More details

$335 / 0.01 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
IL-31R beta (OSMRb) (IL31R), Recombinant Protein
Full Product Name
Mouse IL-31R beta Recombinant (OSMRb)
Product Gene Name
IL31R recombinant protein
Product Synonym Gene Name
IL-31R
Product Synonym Names
Mouse IL-31R beta Recombinant (OSMR) ; OSMRB; IL31RB; il-31RB; receptor
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant mouse IL-31RB (OSM-R) is supplied as a 0.2 um filtered PBS solution, pH7.2.
Purity/Purification
>97%, as determined by SDS-PAGE and HPLC
Preparation and Storage
Recombinant mouse IL-31 receptor beta, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.
Molecular Weight
110,229 Da
3D Structure
ModBase 3D Structure for O70458
Domain
Sushi
Host Note
Optimized DNA sequence encoding extracellular domain of mouse Interleukin-31 receptor beta subunit (OSM-Rb) including a C-terminal tag was expressed in HEK293 cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Recombinant mouse IL-31RB is a monomer protein consisting of 725 amino acid residue subunits, due to glycosylation migrates as an approximately 130 kDa protein on SDS-PAGE.

Product Categories/Family for IL31R recombinant protein

Receptors CD

Other Notes

Small volumes of IL31R recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL31R purchase

MBS553291 is a recombinant protein targeting IL31R. Also known as Mouse IL-31R beta Recombinant (OSMRb). Host: HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for IL31R. It may not necessarily be applicable to this product.

NCBI GI #
162287202
NCBI GeneID
18414
NCBI Accession #
NP_035149.2
UniProt Primary Accession #
O70458
UniProt Secondary Accession #
O88821
GenBank Nucleotide #
NM_011019.3
NCBI Official Full Name
oncostatin-M-specific receptor subunit beta
UniProt Protein Name
Oncostatin-M-specific receptor subunit beta
UniProt Synonym Protein Names
Interleukin-31 receptor subunit beta
UniProt Gene Name
Osmr
UniProt Synonym Gene Names
Osmrb; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB
UniProt Entry Name
OSMR_MOUSE

UniProt Comments for IL31R

OSMR: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1); also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: membrane; oncostatin-M receptor complex; integral to plasma membrane; integral to membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; oncostatin-M receptor activity; growth factor binding

Biological Process: cell surface receptor linked signal transduction; response to cytokine stimulus; positive regulation of cell proliferation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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