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Il-17rc (IL17RC) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553299

IL-17 is a potent regulator of the neutrophil response. Both IL-17A and IL-17F are capable of signaling through IL-17RA to induce granulopoietic factors such as G-CSF and stem cell factor which leads to expansion of neutrophil progenitors in the bone marrow… More details

$335 / 0.02 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
IL-17RC (IL17RC), Recombinant Protein
Full Product Name
Human IL-17RC Recombinant
Product Gene Name
IL17RC recombinant protein
Product Synonym Gene Name
IL-17R
Product Synonym Names
il-17rc; il17RC; interleukin-17 r
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant Interleukin-17RC is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
Purity/Purification
>98%, as determined by SDS-PAGE and HPLC
Preparation and Storage
Recombinant IL-17RC, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.
Molecular Weight
86,240 Da
OMIM
610925
3D Structure
ModBase 3D Structure for Q8NAC3
Host Note
Optimized DNA sequence encoding extracellular domain of human IL-17RC receptor including a C terminal His tag was expressed in HEK293 cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Recombinant IL17RC is a monomer protein consisting of 444 amino acid residue subunits, due to glycosylation migrates as an approximately 50kD protein under reducing SDS-PAGE conditions.

Product Categories/Family for IL17RC recombinant protein

Receptors CD

Other Notes

Small volumes of IL17RC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17RC purchase

MBS553299 is a recombinant protein targeting IL17RC. Also known as Human IL-17RC Recombinant. Host: HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for IL17RC. It may not necessarily be applicable to this product.

NCBI GI #
322812168
NCBI GeneID
84818
NCBI Accession #
NP_001190192.1
UniProt Primary Accession #
Q8NAC3
UniProt Secondary Accession #
Q6UVY3; Q6UWD4; Q8NFS1; Q9BR97
GenBank Nucleotide #
NM_001203263.1
NCBI Official Full Name
interleukin-17 receptor C isoform 4
UniProt Protein Name
Interleukin-17 receptor C
UniProt Synonym Protein Names
Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14
Protein Family
Interleukin-17 receptor
UniProt Gene Name
IL17RC
UniProt Synonym Gene Names
IL-17 receptor C; IL-17RC; IL17Rhom; IL-17RL
UniProt Entry Name
I17RC_HUMAN

NCBI Summary for IL17RC

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
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UniProt Comments for IL17RC

IL17RC: a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p25.3|3p25.3-p24.1

Cellular Component: integral to plasma membrane

Molecular Function: interleukin-17 receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway

Disease: Candidiasis, Familial, 9
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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