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Il-31r Beta (OSMR) (IL31R) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553306

Two types of functional hOSM receptors are known: the type I OSM receptor is identical to the LIF receptor that consists of gp130 and the LIF receptor β subunit (LIFRβ), and the type II OSM receptor consists of gp130 and the OSM receptor β subunit (OSMRβ). More details

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Product Overview

Product Name
IL-31R beta (OSMR) (IL31R), Recombinant Protein
Full Product Name
Human IL-31R beta Recombinant (OSMR)
Product Gene Name
IL31R recombinant protein
Product Synonym Gene Name
IL-31R
Product Synonym Names
Human IL-31R beta Recombinant (OSMR) ; OSMRB; IL31RB; il-31RB; receptor
Host
HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant IL-31RB is supplied as a 0.2 um filtered PBS solution, pH7.2.
Purity/Purification
>97%, as determined by SDS-PAGE and HPLC
Preparation and Storage
Recombinant IL-31 receptor beta, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.
Molecular Weight
61,117 Da
OMIM
146710
3D Structure
ModBase 3D Structure for P14784
Domain
Sushi
Host Note
Optimized DNA sequence encoding extracellular domain of human Interleukin-31 receptor beta subunit including a C-terminal tag was expressed in HEK293 cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Recombinant IL-31RB is a monomer protein consisting of 724 amino acid residue subunits, due to glycosylation migrates as an approximately 130 kDa protein on SDS-PAGE.

Product Categories/Family for IL31R recombinant protein

Receptors CD

Other Notes

Small volumes of IL31R recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL31R purchase

MBS553306 is a recombinant protein targeting IL31R. Also known as Human IL-31R beta Recombinant (OSMR). Host: HEk293 Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for IL31R. It may not necessarily be applicable to this product.

NCBI GI #
4504665
NCBI GeneID
3560
NCBI Accession #
NP_000869.1
UniProt Primary Accession #
P14784
UniProt Secondary Accession #
B2R765
GenBank Nucleotide #
NM_000878.3
NCBI Official Full Name
interleukin-2 receptor subunit beta
UniProt Protein Name
Interleukin-2 receptor subunit beta
UniProt Synonym Protein Names
High affinity IL-2 receptor subunit beta; p70-75
UniProt Gene Name
IL2RB
UniProt Synonym Gene Names
IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; p75
UniProt Entry Name
IL2RB_HUMAN

NCBI Summary for IL31R

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL31R

IL2RB: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: interleukin-2 receptor activity; interleukin-2 binding

Biological Process: viral reproduction; cytokine and chemokine mediated signaling pathway; protein complex assembly; signal transduction; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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