• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

FGF18 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553635

MBS553635 is an active protein targeting FGF18. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders). More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
FGF18, Active Protein
Full Product Name
FGF18
Product Gene Name
FGF18 active protein
Sequence
AEENVDFRI HVENQTRARD DVSRKQLRLY QLYSRTSGKH IQVLGRRISA RGEDGDKYAQ LLVETDTFGS QVRIKGKETE FYLCMNRKGK LVGKPDGTSK ECVFIEKVLE NNYTALMSAK YSGWYVGFTK KGRPRKGPKT RENQQDVHFM KRYPKGQPEL QKPFKYTTVT KRSR
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Lyophilized; PBS, pH 7.2
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC.
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this product can be stored in working aliquots at 2 degree C - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
23,989 Da
3D Structure
ModBase 3D Structure for O76093
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Source Note
Optimized DNA sequence encoding Human FGF18 mature chain including a C-terminal 6xHis tag was expressed in ECOLI. Recombinant Human Fibroblast growth factor 18 encodes amino acid residues 28-207.
Biological Activity
Determined by thymidine uptake by BaF3 cells expressing FGF-receptors is = 0.5 ng/ml, corresponding to a specific activity of = 2 x 10^6 units/mg.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Applications Tested/Suitable for FGF18 active protein
SDS-PAGE
Application Notes for FGF18 active protein
Recombinant FGF18 migrates as an approximately 19 kDa protein under reducing conditions in SDS-PAGE.

Other Notes

Small volumes of FGF18 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF18. It may not necessarily be applicable to this product.

NCBI GI #
4503695
NCBI GeneID
8817
NCBI Accession #
NP_003853.1
UniProt Primary Accession #
O76093
UniProt Secondary Accession #
Q6UWF1; D3DQL7
UniProt Related Accession #
O76093
GenBank Nucleotide #
NM_003862.3
NCBI Official Full Name
fibroblast growth factor 18
NCBI Official Synonym Full Names
fibroblast growth factor 18
NCBI Official Symbol
FGF18
NCBI Official Synonym Symbols
ZFGF5; FGF-18
UniProt Protein Name
Fibroblast growth factor 18
UniProt Synonym Protein Names
zFGF5
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF18
UniProt Synonym Gene Names
FGF-18
NCBI Protein Information
fibroblast growth factor 18

NCBI Summary for FGF18

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for FGF18

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.

Research Articles on FGF18

1. FGF18 played an important role in the growth and metastasis of breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF18 active protein

 Reference Product  PubMed Publications
 FGFR3 active protein  >23 publications with FGF18 and FGFR3
 FGFR2 active protein  >17 publications with FGF18 and FGFR2
 FGFR1 active protein  >17 publications with FGF18 and FGFR1
 FGFR4 active protein  >8 publications with FGF18 and FGFR4

Pathways associated with FGF18 active protein

 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram

Diseases associated with FGF18 active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with FGF18 and Neoplasms
 Craniofacial Abnormalities Antibodies  >5 publications with FGF18 and Craniofacial Abnormalities
 Hypertrophy Antibodies  >4 publications with FGF18 and Hypertrophy
 Nervous System Diseases Antibodies  >3 publications with FGF18 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with FGF18 and Brain Diseases
 Liver Neoplasms Antibodies  >2 publications with FGF18 and Liver Neoplasms
 Inflammation Antibodies  >2 publications with FGF18 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >1 publications with FGF18 and Cell Transformation, Neoplastic
 Autoimmune Diseases Antibodies  >1 publications with FGF18 and Autoimmune Diseases
 Nervous System Malformations Antibodies  >1 publications with FGF18 and Nervous System Malformations

Organs/Tissues associated with FGF18 active protein

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >13 publications with FGF18 and Embryonic Tissue
 Connective Tissue Antibodies  >13 publications with FGF18 and Connective Tissue
 Lung Antibodies  >9 publications with FGF18 and Lung
 Heart Antibodies  >4 publications with FGF18 and Heart
 Intestine Antibodies  >2 publications with FGF18 and Intestine
 Placenta Antibodies  >2 publications with FGF18 and Placenta
 Eye Antibodies  >1 publications with FGF18 and Eye
 Ovary Antibodies  >1 publications with FGF18 and Ovary
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000