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FGF6 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553654

MBS553654 is an active protein targeting FGF6. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FGF6, Active Protein
Full Product Name
FGF6
Product Gene Name
FGF6 active protein
Sequence
GTRANNTLLD SRGWGTLLSR SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY IALSKYGRVK RGSKVSPIMT VTHFLPRI
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Lyophilized; PBS, pH 7.2
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC.
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this product can be stored in working aliquots at 2 degree C - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
22,905 Da
3D Structure
ModBase 3D Structure for P10767
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Source Note
Optimized DNA sequence encoding Human FGF6 mature chain was expressed in ECOLI. Recombinant Human Fibroblast growth factor 6 encodes amino acid residues 38-208.
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is = 0.5 ng/ml
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Applications Tested/Suitable for FGF6 active protein
SDS-PAGE
Application Notes for FGF6 active protein
Recombinant FGF6 migrates as an approximately 18 kDa protein under reducing conditions in SDS-PAGE.

Other Notes

Small volumes of FGF6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF6. It may not necessarily be applicable to this product.

NCBI GI #
673414
NCBI GeneID
2251
NCBI Accession #
CAA40360.1
UniProt Primary Accession #
P10767
UniProt Secondary Accession #
Q0VAE1
UniProt Related Accession #
P10767
NCBI Official Full Name
FGF6, partial
NCBI Official Synonym Full Names
fibroblast growth factor 6
NCBI Official Symbol
FGF6
NCBI Official Synonym Symbols
HST2; HBGF-6
UniProt Protein Name
Fibroblast growth factor 6
UniProt Synonym Protein Names
Heparin secretory-transforming protein 2; HST-2; HSTF-2; Heparin-binding growth factor 6; HBGF-6
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF6
UniProt Synonym Gene Names
HST2; HSTF2; FGF-6; HST-2; HSTF-2; HBGF-6
NCBI Protein Information
fibroblast growth factor 6

NCBI Summary for FGF6

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]
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UniProt Comments for FGF6

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.

Research Articles on FGF6

1. These data demonstrate that FGF-6 may be considered a regulator of bone metabolism as shown by its activity on both osteoblasts and osteoclasts.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF6 active protein

 Reference Product  PubMed Publications
 FGFR4 active protein  >15 publications with FGF6 and FGFR4
 FGF1 active protein  >12 publications with FGF6 and FGF1
 FGF3 active protein  >11 publications with FGF6 and FGF3
 FGFR1 active protein  >11 publications with FGF6 and FGFR1
 FGF7 active protein  >10 publications with FGF6 and FGF7
 FGFR2 active protein  >9 publications with FGF6 and FGFR2
 FGF9 active protein  >7 publications with FGF6 and FGF9
 FGF10 active protein  >6 publications with FGF6 and FGF10
 FGFR3 active protein  >6 publications with FGF6 and FGFR3
 FGF23 active protein  >5 publications with FGF6 and FGF23

Pathways associated with FGF6 active protein

 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram

Diseases associated with FGF6 active protein

 Disease Name  Pubmed Publications
 Hypertrophy Antibodies  >6 publications with FGF6 and Hypertrophy
 Cell Transformation, Neoplastic Antibodies  >5 publications with FGF6 and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >5 publications with FGF6 and Carcinoma
 Breast Neoplasms Antibodies  >5 publications with FGF6 and Breast Neoplasms
 Prostatic Diseases Antibodies  >3 publications with FGF6 and Prostatic Diseases
 Skin Diseases Antibodies  >2 publications with FGF6 and Skin Diseases
 Inflammation Antibodies  >2 publications with FGF6 and Inflammation
 Adenocarcinoma Antibodies  >2 publications with FGF6 and Adenocarcinoma
 Hyperplasia Antibodies  >2 publications with FGF6 and Hyperplasia
 Ovarian Neoplasms Antibodies  >1 publications with FGF6 and Ovarian Neoplasms

Organs/Tissues associated with FGF6 active protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >35 publications with FGF6 and Muscle
 Testis Antibodies  >2 publications with FGF6 and Testis
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