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GDF7 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553689

MBS553689 is an active protein targeting GDF7. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GDF7, Active Protein
Full Product Name
GDF7
Product Gene Name
GDF7 active protein
Sequence
MTQGENHPSP NFNQYVRDQG AMTDQLSRRQ IREYQLYSRT SGKHVQVTGR RISATAEDGN KFAKLIVETD TFGSRVRIKG AESEKYICMN KRGKLIGKPS GKSKDCVFTE IVLENNYTAF QNARHEGWFM AFTRQGRPRQ ASRSRQNQRE AHFIKRLYQG QLPFPNHAEK QKQFEFVGSA PTRRTKRTRR PQPLT
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Lyophilized; PBS, pH 7.2
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC.
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this product can be stored in working aliquots at 2 degree C - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
46,950 Da
3D Structure
ModBase 3D Structure for Q7Z4P5
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Source Note
Optimized DNA sequence encoding Human GDF7 mature chain was expressed in ECOLI. Recombinant Human Growth/differentiation factor 7 encodes amino acid residues 322-450.
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is = 0.5 ng/ml
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Applications Tested/Suitable for GDF7 active protein
SDS-PAGE
Application Notes for GDF7 active protein
Recombinant GDF7 migrates as an approximately 21 kDa protein under reducing conditions in SDS-PAGE.

Other Notes

Small volumes of GDF7 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF7. It may not necessarily be applicable to this product.

NCBI GI #
61835232
NCBI GeneID
151449
NCBI Accession #
NP_878248.2
UniProt Primary Accession #
Q7Z4P5
UniProt Related Accession #
Q7Z4P5
GenBank Nucleotide #
NM_182828.4
NCBI Official Full Name
growth/differentiation factor 7 preproprotein
NCBI Official Synonym Full Names
growth differentiation factor 7
NCBI Official Symbol
GDF7
NCBI Official Synonym Symbols
BMP12
UniProt Protein Name
Growth/differentiation factor 7
Protein Family
Growth/differentiation factor
UniProt Gene Name
GDF7
UniProt Synonym Gene Names
GDF-7
NCBI Protein Information
growth/differentiation factor 7

NCBI Summary for GDF7

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]
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UniProt Comments for GDF7

May play an active role in the motor area of the primate neocortex.

Research Articles on GDF7

1. BMP-12 activates tenogenic pathway in human adipose stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDF7 active protein

 Reference Product  PubMed Publications
 BMP7 active protein  >4 publications with GDF7 and BMP7

Pathways associated with GDF7 active protein

 Products by Pathway  Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with GDF7 active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with GDF7 and Neoplasms
 Genital Diseases, Male Antibodies  >1 publications with GDF7 and Genital Diseases, Male
 Burns Antibodies  >1 publications with GDF7 and Burns
 Infertility, Male Antibodies  >1 publications with GDF7 and Infertility, Male

Organs/Tissues associated with GDF7 active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with GDF7 and Brain
 Testis Antibodies  >1 publications with GDF7 and Testis
 Kidney Antibodies  >1 publications with GDF7 and Kidney
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