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CCL4L1 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553692

MBS553692 is an active protein targeting CCL4L1. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CCL4L1, Active Protein
Full Product Name
CCL4L1
Product Gene Name
CCL4L1 active protein
Sequence
APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Lyophilized; PBS, pH 7.2
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC.
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this product can be stored in working aliquots at 2 degree C - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
9,505 Da
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Source Note
Optimized DNA sequence encoding Human CCL4L1 mature chain was expressed in ECOLI. Recombinant Human C-C motif chemokine 4-like encodes amino acid residues 24-92.
Biological Activity
Determined by its ability to chemoattract CCR5-transfected cells using a concentration of 0.1-10.0 ng/ml
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Applications Tested/Suitable for CCL4L1 active protein
SDS-PAGE
Application Notes for CCL4L1 active protein
Recombinant CCL4L1 migrates as an approximately 8 kDa protein under reducing conditions in SDS-PAGE.

Other Notes

Small volumes of CCL4L1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL4L1. It may not necessarily be applicable to this product.

NCBI GI #
46275832
NCBI GeneID
388372
NCBI Accession #
NP_996890.1
UniProt Secondary Accession #
Q50EM1; Q50EM2; Q50EM3; Q50EM4; Q50EM5; Q50EM6; Q50EM7; Q50EM8; Q569J2; B2RUZ3; B7ZMA8
UniProt Related Accession #
Q8NHW4
GenBank Nucleotide #
NM_207007.3
NCBI Official Full Name
C-C motif chemokine 4-like
NCBI Official Synonym Full Names
C-C motif chemokine ligand 4 like 1
NCBI Official Symbol
CCL4L1
NCBI Official Synonym Symbols
LAG1; CCL4L; LAG-1; SCYA4L; AT744.2; SCYA4L1; SCYA4L2; MIP-1-beta
UniProt Protein Name
C-C motif chemokine 4-like
UniProt Synonym Protein Names
Lymphocyte activation gene 1 protein; LAG-1; Macrophage inflammatory protein 1-beta; MIP-1-beta; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL4L1
UniProt Synonym Gene Names
CCL4L; LAG1; SCYA4L1; LAG-1; MIP-1-beta
NCBI Protein Information
C-C motif chemokine 4-like

NCBI Summary for CCL4L1

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
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UniProt Comments for CCL4L1

Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Research Articles on CCL4L1

1. identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CCL4L1 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Diseases associated with CCL4L1 active protein

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4 publications with CCL4L1 and Immune System Diseases
 Disease Progression Antibodies  >3 publications with CCL4L1 and Disease Progression
 Disease Susceptibility Antibodies  >3 publications with CCL4L1 and Disease Susceptibility
 Diabetes Mellitus Antibodies  >1 publications with CCL4L1 and Diabetes Mellitus

Organs/Tissues associated with CCL4L1 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with CCL4L1 and Blood
 Kidney Antibodies  >2 publications with CCL4L1 and Kidney
 Liver Antibodies  >1 publications with CCL4L1 and Liver
 Lung Antibodies  >1 publications with CCL4L1 and Lung
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