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NRN1 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553708

MBS553708 is an active protein targeting NRN1. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NRN1, Active Protein
Full Product Name
NRN1
Product Gene Name
NRN1 active protein
Sequence
AGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFHSCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGN
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Lyophilized; PBS, pH 7.2
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC.
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this product can be stored in working aliquots at 2 degree C - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
15,333 Da
3D Structure
ModBase 3D Structure for Q9NPD7
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Source Note
Optimized DNA sequence encoding Human NRN1 mature chain was expressed in ECOLI. Recombinant Human Neuritin encodes amino acid residues 28-116.
Biological Activity
Determined by a cell proliferation using rat C6 cells. The ED50 for this effect is 20.0-30.0 ng/ml.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Applications Tested/Suitable for NRN1 active protein
SDS-PAGE
Application Notes for NRN1 active protein
Recombinant NRN1 migrates as an approximately 10 kDa protein under reducing conditions in SDS-PAGE.

Other Notes

Small volumes of NRN1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NRN1. It may not necessarily be applicable to this product.

NCBI GI #
7706123
NCBI GeneID
51299
NCBI Accession #
NP_057672.1
UniProt Primary Accession #
Q9NPD7
UniProt Secondary Accession #
Q7Z4Y1; B2RA93
UniProt Related Accession #
Q9NPD7
GenBank Nucleotide #
NM_016588.3
NCBI Official Full Name
neuritin isoform 1
NCBI Official Synonym Full Names
neuritin 1
NCBI Official Symbol
NRN1
NCBI Official Synonym Symbols
NRN; dJ380B8.2
UniProt Protein Name
Neuritin
Protein Family
Neuritin
UniProt Gene Name
NRN1
UniProt Synonym Gene Names
NRN
NCBI Protein Information
neuritin

NCBI Summary for NRN1

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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UniProt Comments for NRN1

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.

Research Articles on NRN1

1. NRN1 is expressed more extensively in melanoma than in normal melanocytes and healthy tissue. Secreted NRN1 seems to play a role also in earlier phases of melanoma development as we can discover NRN1 over-expression to be associated to primary melanoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NRN1 active protein

 Reference Product  PubMed Publications
 BDNF active protein  >5 publications with NRN1 and BDNF
 NGF active protein  >2 publications with NRN1 and NGF
 NTF3 active protein  >1 publications with NRN1 and NTF3

Diseases associated with NRN1 active protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >9 publications with NRN1 and Brain Diseases
 Disease Models, Animal Antibodies  >5 publications with NRN1 and Disease Models, Animal
 Metaplasia Antibodies  >3 publications with NRN1 and Metaplasia
 Neurobehavioral Manifestations Antibodies  >2 publications with NRN1 and Neurobehavioral Manifestations
 Breast Neoplasms Antibodies  >2 publications with NRN1 and Breast Neoplasms
 Atrophy Antibodies  >2 publications with NRN1 and Atrophy
 Respiratory Tract Diseases Antibodies  >1 publications with NRN1 and Respiratory Tract Diseases
 Growth Disorders Antibodies  >1 publications with NRN1 and Growth Disorders
 Hypertension Antibodies  >1 publications with NRN1 and Hypertension
 Kidney Diseases Antibodies  >1 publications with NRN1 and Kidney Diseases

Organs/Tissues associated with NRN1 active protein

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >21 publications with NRN1 and Nerve
 Brain Antibodies  >21 publications with NRN1 and Brain
 Eye Antibodies  >8 publications with NRN1 and Eye
 Blood Antibodies  >4 publications with NRN1 and Blood
 Embryonic Tissue Antibodies  >3 publications with NRN1 and Embryonic Tissue
 Muscle Antibodies  >2 publications with NRN1 and Muscle
 Liver Antibodies  >1 publications with NRN1 and Liver
 Spleen Antibodies  >1 publications with NRN1 and Spleen
 Lung Antibodies  >1 publications with NRN1 and Lung
 Heart Antibodies  >1 publications with NRN1 and Heart
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