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TNFRSF11A Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553716

MBS553716 is an active protein targeting TNFRSF11A. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TNFRSF11A, Active Protein
Full Product Name
TNFRSF11A
Product Gene Name
TNFRSF11A active protein
Sequence
MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Lyophilized; PBS, pH 7.2
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC.
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this product can be stored in working aliquots at 2 degree C - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
32,318 Da
3D Structure
ModBase 3D Structure for Q9Y6Q6
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Source Note
Optimized DNA sequence encoding Human TNFRSF11A mature chain was expressed in ECOLI. Recombinant Human Tumor necrosis factor receptor superfamily member 11A encodes amino acid residues 30-616.
Biological Activity
Determined by its ability to inhibit sRANKL induced NF-B in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect in the presence of 15 ng/ml of recombinant sRANKL, is 30-50 ng/ml.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Applications Tested/Suitable for TNFRSF11A active protein
SDS-PAGE
Application Notes for TNFRSF11A active protein
Recombinant TNFRSF11A migrates as an approximately 19 kDa protein under reducing conditions in SDS-PAGE.

Other Notes

Small volumes of TNFRSF11A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF11A. It may not necessarily be applicable to this product.

NCBI GI #
506327990
NCBI GeneID
8792
NCBI Accession #
NP_001265197.1
UniProt Primary Accession #
Q9Y6Q6
UniProt Secondary Accession #
Q59EP9; I4EC36; I4EC38; I4EC39; I7JE63; N0GVH0
UniProt Related Accession #
Q9Y6Q6
GenBank Nucleotide #
NM_001278268.1
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 11A isoform 5
NCBI Official Synonym Full Names
TNF receptor superfamily member 11a
NCBI Official Symbol
TNFRSF11A
NCBI Official Synonym Symbols
FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 11A
UniProt Synonym Protein Names
Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD_antigen: CD265
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF11A
UniProt Synonym Gene Names
RANK; ODFR
NCBI Protein Information
tumor necrosis factor receptor superfamily member 11A

NCBI Summary for TNFRSF11A

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
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UniProt Comments for TNFRSF11A

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.

Research Articles on TNFRSF11A

1. RANK/RANKL were identified as crucial regulators for BRCA1 mutation-driven breast cancer. Current prevention strategies for BRCA1 mutation carriers are associated with wide-ranging risks; therefore, the search for alternative, non-invasive strategies is of paramount importance

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFRSF11A active protein

 Reference Product  PubMed Publications
 TNFSF11 active protein  >1537 publications with TNFRSF11A and TNFSF11
 TRAF6 active protein  >62 publications with TNFRSF11A and TRAF6
 TRAF2 active protein  >15 publications with TNFRSF11A and TRAF2
 TRAF1 active protein  >8 publications with TNFRSF11A and TRAF1
 TRAF5 active protein  >8 publications with TNFRSF11A and TRAF5
 TRAF3 active protein  >6 publications with TNFRSF11A and TRAF3
 TEC active protein  >4 publications with TNFRSF11A and TEC
 VEGFA active protein  >3 publications with TNFRSF11A and VEGFA
 BTK active protein  >1 publications with TNFRSF11A and BTK

Pathways associated with TNFRSF11A active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 RANKL/RANK Signaling Pathway antibodies  RANKL/RANK Signaling Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram

Diseases associated with TNFRSF11A active protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >883 publications with TNFRSF11A and Necrosis
 Inflammation Antibodies  >147 publications with TNFRSF11A and Inflammation
 Cardiovascular Diseases Antibodies  >108 publications with TNFRSF11A and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >59 publications with TNFRSF11A and Breast Neoplasms
 Osteitis Deformans Antibodies  >48 publications with TNFRSF11A and Osteitis Deformans
 Neoplasm Metastasis Antibodies  >40 publications with TNFRSF11A and Neoplasm Metastasis
 Osteosarcoma Antibodies  >29 publications with TNFRSF11A and Osteosarcoma
 Kidney Diseases Antibodies  >21 publications with TNFRSF11A and Kidney Diseases
 Neoplasms, Experimental Antibodies  >19 publications with TNFRSF11A and Neoplasms, Experimental
 Heart Diseases Antibodies  >17 publications with TNFRSF11A and Heart Diseases

Organs/Tissues associated with TNFRSF11A active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1362 publications with TNFRSF11A and Bone
 Vascular Antibodies  >76 publications with TNFRSF11A and Vascular
 Brain Antibodies  >21 publications with TNFRSF11A and Brain
 Heart Antibodies  >20 publications with TNFRSF11A and Heart
 Liver Antibodies  >20 publications with TNFRSF11A and Liver
 Skin Antibodies  >19 publications with TNFRSF11A and Skin
 Embryonic Tissue Antibodies  >19 publications with TNFRSF11A and Embryonic Tissue
 Lung Antibodies  >18 publications with TNFRSF11A and Lung
 Kidney Antibodies  >18 publications with TNFRSF11A and Kidney
 Intestine Antibodies  >8 publications with TNFRSF11A and Intestine
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