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NEUROFILAMENT NF-L Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555054

Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. In the electron microscope neurofilaments appears as 10nm diameter fibres of indeterminate length which generally have fine wispy protrusions from… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Neurofilament NF-L, Antibody
Full Product Name
Neurofilament NF-L
Product Gene Name
anti-Neurofilament NF-L antibody
Species Reactivity
Cat, Chicken, Human, Mouse, Rat
Form/Format
Supernatant - Liquid
Molecular Weight
61,517 Da
OMIM
162280
Type Info
Mouse IgG
Immunogen
Enzymatically dephosphorylated pig neurofilaments; screened and selected for NF-L specificity

Product Categories/Family for anti-Neurofilament NF-L antibody

Antibodies; Stem Cell Research Antibodies; Neurofilament NF-L
Applications Tested/Suitable for anti-Neurofilament NF-L antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB), ELISA (EIA)

Testing Data of anti-Neurofilament NF-L antibody

Image: Cells grown from adult rat brain. Large cell in middle is stained with mouse monoclonal to NF-L clone DA2 (green). Another type of neuronal lineage cell was stained with rabbit polyclonal to alpha-internexin (red). These cells were mitotic but had several characteristics of neurons. Protocol on datasheet.
Anti-NEUROFILAMENT NF-L Antibody – Cat# MBS555054

Testing Data of anti-Neurofilament NF-L antibody

Image: Rat spinal cord homogenate showing the major intermediate filament proteins of the nervous system (lane 1). The remaining lanes show blots of this material stainted with various antibodies including NF-L.
Anti-NEUROFILAMENT NF-L Antibody, Testing Data – Cat# MBS555054

Other Notes

Small volumes of anti-Neurofilament NF-L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Neurofilament NF-L purchase

MBS555054 is an antibody targeting Neurofilament NF-L. Reactive in Cat, Chicken, Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for Neurofilament NF-L. It may not necessarily be applicable to this product.

NCBI GI #
105990539
NCBI GeneID
4747
NCBI Accession #
NP_006149.2
UniProt Secondary Accession #
Q16154; Q8IU72; B9ZVN2
UniProt Related Accession #
P07196
GenBank Nucleotide #
NM_006158.4
NCBI Official Full Name
neurofilament light polypeptide
NCBI Official Synonym Full Names
neurofilament, light polypeptide
NCBI Official Symbol
NEFL
NCBI Official Synonym Symbols
NFL; NF-L; NF68; CMT1F; CMT2E; PPP1R110
UniProt Protein Name
Neurofilament light polypeptide
UniProt Synonym Protein Names
68 kDa neurofilament protein; Neurofilament triplet L protein
UniProt Gene Name
NEFL
UniProt Synonym Gene Names
NF68; NFL; NF-L
UniProt Entry Name
NFL_HUMAN
NCBI Protein Information
neurofilament light polypeptide

NCBI Summary for Neurofilament NF-L

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
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UniProt Comments for Neurofilament NF-L

NFL: one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F).

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: TSC1-TSC2 complex; growth cone; axon; cytoplasm; neurofilament; cytosol

Molecular Function: protein binding, bridging; protein C-terminus binding; protein domain specific binding; identical protein binding; protein binding; phospholipase binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; response to peptide hormone stimulus; neurofilament bundle assembly; response to toxin; intermediate filament organization; microtubule cytoskeleton organization and biogenesis; retrograde axon cargo transport; axon regeneration in the peripheral nervous system; synaptic transmission; axon transport of mitochondrion; regulation of axon diameter; positive regulation of axonogenesis; negative regulation of neuron apoptosis; neuromuscular process controlling balance; anterograde axon cargo transport; locomotion; neurite morphogenesis; response to corticosterone stimulus

Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1f; Charcot-marie-tooth Disease, Axonal, Type 2e
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Research Articles on Neurofilament NF-L

1. Neurofilament light chain protein NF-L has a dynamic role in the reactive and regenerative changes in axons following injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Neurofilament NF-L antibody

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram

Diseases associated with anti-Neurofilament NF-L antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >67 publications with Neurofilament NF-L and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >55 publications with Neurofilament NF-L and Peripheral Nervous System Diseases
 Nervous System Malformations Antibodies  >52 publications with Neurofilament NF-L and Nervous System Malformations
 Breast Neoplasms Antibodies  >9 publications with Neurofilament NF-L and Breast Neoplasms
 Brain Diseases Antibodies  >8 publications with Neurofilament NF-L and Brain Diseases
 Disease Models, Animal Antibodies  >5 publications with Neurofilament NF-L and Disease Models, Animal
 Charcot-Marie-Tooth disease, Type 2E Antibodies  >4 publications with Neurofilament NF-L and Charcot-Marie-Tooth disease, Type 2E
 Ataxia Antibodies  >3 publications with Neurofilament NF-L and Ataxia
 Lung Neoplasms Antibodies  >2 publications with Neurofilament NF-L and Lung Neoplasms
 Hypertension Antibodies  >2 publications with Neurofilament NF-L and Hypertension

Organs/Tissues associated with anti-Neurofilament NF-L antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >42 publications with Neurofilament NF-L and Nerve
 Brain Antibodies  >31 publications with Neurofilament NF-L and Brain
 Prostate Antibodies  >11 publications with Neurofilament NF-L and Prostate
 Spinal Cord Antibodies  >9 publications with Neurofilament NF-L and Spinal Cord
 Lung Antibodies  >6 publications with Neurofilament NF-L and Lung
 Eye Antibodies  >3 publications with Neurofilament NF-L and Eye
 Ganglia Antibodies  >2 publications with Neurofilament NF-L and Ganglia
 Embryonic Tissue Antibodies  >2 publications with Neurofilament NF-L and Embryonic Tissue
 Bone Marrow Antibodies  >2 publications with Neurofilament NF-L and Bone Marrow
 Kidney Antibodies  >2 publications with Neurofilament NF-L and Kidney
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