Image: TRPM2 (red) and GFAP (green) staining of rat hippocampus. Nclei staining is blue. Image courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand.

TRPM2 Antibody

Name: TRPM2 Antibody; Mouse/Rat-Reactive; Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS555148
Price: 635 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555148

TRPM2 is a member of the melastatin-related TRPM subfamily belonging to the transient receptor potential or TRP channel superfamily. TRPM2 can form a Ca2+-permeable cationic channel activated by intracellular ADP-ribose. The physiological functions of TRPM2… More details

$635 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRPM2, Antibody

Full Product Name

TRPM2, Affinity Purified Antibody, Rabbit

Product Gene Name

anti-TRPM2 antibody

Species Reactivity

Mouse, Rat

Form/Format

Affinity Purified - Liquid

Type Info

Rabbit IgG

Immunogen

Synthetic peptide made to a C-terminal portion of the rat protein (within residues 1430-1508). [Swiss-Prot# Q5G856].

Product Categories/Family for anti-TRPM2 antibody

Antibodies; TRPV (Vanilloid); TRPM; TRPA and TRPCs; TRPM2

Applications Tested/Suitable for anti-TRPM2 antibody

Immunohistochemistry (IHC), Western Blot (WB)

Other Notes

Small volumes of anti-TRPM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRPM2 purchase

MBS555148 is an antibody targeting TRPM2. Also known as TRPM2, Affinity Purified Antibody, Rabbit. Reactive in Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPM2. It may not necessarily be applicable to this product.

NCBI GI #

NCBI GeneID

NCBI Accession #

GenBank Nucleotide #

NCBI Official Full Name

transient receptor potential cation channel subfamily M member 2

NCBI Official Synonym Full Names

transient receptor potential cation channel, subfamily M, member 2

NCBI Official Symbol

Trpm2

NCBI Official Synonym Symbols

Trpm2-predicted

Protein Family

Transient receptor potential cation channel subfamily

NCBI Protein Information

transient receptor potential cation channel subfamily M member 2

UniProt Comments for TRPM2

TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Hydrolase; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; EC 3.6.1.13

Cellular Component: integral to membrane; plasma membrane

Molecular Function: ADP-ribose diphosphatase activity; cation channel activity; manganese ion transmembrane transporter activity

Biological Process: response to hydroperoxide; metabolic process; manganese ion transport

Research Articles on TRPM2

1. This study demonistrated that Chronic oxidative stress modulates TRPM2 channel expression and function in rat primary cortical neurons

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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