FE65 Antibody

Fe65: adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Y142 (H2AXpY142) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as TIP60, probably explains its trancription activation activity.

Protein type: Apoptosis; Transcription regulation; Adaptor/scaffold

Cellular Component: presynaptic membrane; postsynaptic membrane; growth cone; protein complex; lamellipodium; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic spine; nuclear speck; synapse; nucleus

Molecular Function: protein binding; histone binding; beta-amyloid binding; protein complex binding; chromatin binding; transcription factor binding

Biological Process: axon guidance; extracellular matrix organization and biogenesis; positive regulation of DNA repair; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; neuron migration; negative regulation of thymidylate synthase biosynthetic process; negative regulation of neuron differentiation; regulation of transcription, DNA-dependent; positive regulation of protein secretion; double-strand break repair; visual learning; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; cell cycle arrest; response to DNA damage stimulus; response to iron ion