Image: Mixed rat neuron/glial cultures stained with PGP9.5/UCHL1 (green). Blue is a DNA stain. Note that the UCHL1 stains neurons strongly and specifically, and that the staining is concentrated in the cell bodies, though some does extend into the dendrites also. Surrounding glial cells are not stained with this antibody, though many are present as visualized using the DNA stain. Inset: Blot of whole bovine brain extract stained with PGP9.5/UCHL1 showing a strong and clean band at about 24kDa. Protocol on Data-sheet.

PGP9.5/UCHL1 Antibody

Name: PGP9.5/UCHL1 Antibody; Bovine/Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS555185
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555185

PGP9.5, Park5 or UCHL1 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. It is an excellent marker for neurons of the CNS and PNS. More details

$520 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

UCHL1 (PGP9.5/UCHL1), Antibody

Full Product Name

UCHL1, Antiserum, Rabbit

Product Gene Name

anti-PGP9.5/UCHL1 antibody

Species Reactivity

Bovine, Human, Mouse, Primate, Rat

Form/Format

Whole serum - Liquid

Molecular Weight

24,824 Da

OMIM

191342

Type Info

Rabbit IgG

Immunogen

Recombinant full length human PGP9.5 or UCHL1 purified from E Coli.

Product Categories/Family for anti-PGP9.5/UCHL1 antibody

Antibodies; PGP 9.5s/UCHL1s; PGP9.5/UCHL1

Applications Tested/Suitable for anti-PGP9.5/UCHL1 antibody

Immunofluorescence (IF), Western Blot (WB)

Other Notes

Small volumes of anti-PGP9.5/UCHL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGP9.5/UCHL1 purchase

MBS555185 is an antibody targeting PGP9.5/UCHL1. Also known as UCHL1, Antiserum, Rabbit. Reactive in Bovine, Human, Mouse, Primate, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for PGP9.5/UCHL1. It may not necessarily be applicable to this product.

NCBI GI #

21361091

NCBI GeneID

7345

NCBI Accession #

NP_004172.2

UniProt Secondary Accession #

Q4W5K6; Q71UM0

UniProt Related Accession #

P09936

GenBank Nucleotide #

NM_004181.4

NCBI Official Full Name

ubiquitin carboxyl-terminal hydrolase isozyme L1

NCBI Official Synonym Full Names

ubiquitin C-terminal hydrolase L1

NCBI Official Symbol

UCHL1

NCBI Official Synonym Symbols

NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5; HEL-S-53

UniProt Protein Name

Ubiquitin carboxyl-terminal hydrolase isozyme L1

UniProt Synonym Protein Names

Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1

UniProt Gene Name

UCHL1

UniProt Synonym Gene Names

UCH-L1; PGP9.5

UniProt Entry Name

UCHL1_HUMAN

NCBI Protein Information

ubiquitin carboxyl-terminal hydrolase isozyme L1

UniProt Comments for PGP9.5/UCHL1

UCHL1: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family.

Protein type: Cell development/differentiation; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: cytoplasm; nucleoplasm; plasma membrane

Molecular Function: alpha-2A adrenergic receptor binding; cysteine-type endopeptidase activity; omega peptidase activity; protein binding; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity

Biological Process: negative regulation of MAP kinase activity; protein deubiquitination; regulation of macroautophagy

Disease: Neurodegeneration With Optic Atrophy, Childhood-onset; Parkinson Disease 5, Autosomal Dominant

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PGP9.5/UCHL1 antibody

Reference Product	PubMed Publications
SNCA antibody	>30 publications with PGP9.5/UCHL1 and SNCA
CDKN2A antibody	>4 publications with PGP9.5/UCHL1 and CDKN2A
TP53 antibody	>4 publications with PGP9.5/UCHL1 and TP53
HSP90AA1 antibody	>2 publications with PGP9.5/UCHL1 and HSP90AA1
COPS5 antibody	>1 publications with PGP9.5/UCHL1 and COPS5
HSPA8 antibody	>1 publications with PGP9.5/UCHL1 and HSPA8

Pathways associated with anti-PGP9.5/UCHL1 antibody

Products by Pathway	Pathway Diagram
Alpha-synuclein Signaling Pathway antibodies	Alpha-synuclein Signaling Pathway Diagram
Parkinson's Disease Pathway antibodies	Parkinson's Disease Pathway Diagram
Parkinsons Disease Pathway antibodies	Parkinsons Disease Pathway Diagram
Proteasome Degradation Pathway antibodies	Proteasome Degradation Pathway Diagram

Diseases associated with anti-PGP9.5/UCHL1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>241 publications with PGP9.5/UCHL1 and Nervous System Diseases
Brain Diseases Antibodies	>172 publications with PGP9.5/UCHL1 and Brain Diseases
Movement Disorders Antibodies	>104 publications with PGP9.5/UCHL1 and Movement Disorders
Inflammation Antibodies	>48 publications with PGP9.5/UCHL1 and Inflammation
Disease Models, Animal Antibodies	>43 publications with PGP9.5/UCHL1 and Disease Models, Animal
Peripheral Nervous System Diseases Antibodies	>36 publications with PGP9.5/UCHL1 and Peripheral Nervous System Diseases
Cardiovascular Diseases Antibodies	>35 publications with PGP9.5/UCHL1 and Cardiovascular Diseases
Necrosis Antibodies	>25 publications with PGP9.5/UCHL1 and Necrosis
Nerve Degeneration Antibodies	>22 publications with PGP9.5/UCHL1 and Nerve Degeneration
Brain Injuries Antibodies	>18 publications with PGP9.5/UCHL1 and Brain Injuries

Organs/Tissues associated with anti-PGP9.5/UCHL1 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>218 publications with PGP9.5/UCHL1 and Nerve
Brain Antibodies	>141 publications with PGP9.5/UCHL1 and Brain
Skin Antibodies	>102 publications with PGP9.5/UCHL1 and Skin
Lymph Antibodies	>65 publications with PGP9.5/UCHL1 and Lymph
Muscle Antibodies	>64 publications with PGP9.5/UCHL1 and Muscle
Bone Antibodies	>64 publications with PGP9.5/UCHL1 and Bone
Lymph Node Antibodies	>63 publications with PGP9.5/UCHL1 and Lymph Node
Vascular Antibodies	>60 publications with PGP9.5/UCHL1 and Vascular
Lung Antibodies	>43 publications with PGP9.5/UCHL1 and Lung
Bone Marrow Antibodies	>37 publications with PGP9.5/UCHL1 and Bone Marrow