MOR-1C Antibody

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

MOR-1: a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q24-q25

Cellular Component: dendrite cytoplasm; Golgi apparatus; neuron projection; focal adhesion; integral to plasma membrane; endoplasmic reticulum; plasma membrane; perikaryon; sarcolemma; lipid raft

Molecular Function: voltage-gated calcium channel activity; G-protein coupled receptor activity; neuropeptide binding; protein domain specific binding; protein binding; G-protein beta-subunit binding; G-protein alpha-subunit binding; filamin binding; beta-endorphin receptor activity

Biological Process: positive regulation of nitric oxide biosynthetic process; wound healing; cellular response to stress; locomotory behavior; response to lipopolysaccharide; behavioral response to ethanol; sensory perception of pain; synaptic transmission; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; positive regulation of appetite; sensory perception; acute inflammatory response to antigenic stimulus; dopamine receptor, adenylate cyclase activating pathway; response to food; positive regulation of neurogenesis; negative regulation of nitric oxide biosynthetic process; negative regulation of adenylate cyclase activity; response to cocaine; G-protein signaling, coupled to cyclic nucleotide second messenger; reduction of cytosolic calcium ion concentration; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential

Disease: Epilepsy, Idiopathic Generalized