VR1 Antibody

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]

P2X3: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: Golgi apparatus; cell soma; rough endoplasmic reticulum; integral to plasma membrane; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex; lipid raft

Molecular Function: ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity

Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; generation of action potential; regulation of synaptic plasticity; positive regulation of calcium-mediated signaling; signal transduction; response to carbohydrate stimulus; response to ATP; behavioral response to pain; response to heat; response to mechanical stimulus; transport; response to hypoxia; neuromuscular synaptic transmission; response to cold; protein homooligomerization