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ASIC3 [DRASIC] (ASIC 3) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555355

The acid-sensing ion channel family (ASIC) comprises six discrete ASIC subunits (ASIC 1A, ASIC 1B, ASIC 2A, ASIC 2B, ASIC 3, ASIC 4) that detect tissue acidosis (i.e. a decrease in pH). This acidosis phenomenon is a response to tissue injury, pain and… More details

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Product Overview

Online Datasheet in PDF
Product Name
ASIC3 [DRASIC] (ASIC 3), Polyclonal Antibody
Full Product Name
ASIC3 [DRASIC], Antiserum, guinea pig
Product Gene Name
anti-ASIC 3 antibody
Clonality
Polyclonal
Species Reactivity
Rat
Form/Format
Whole serum - Liquid
Molecular Weight
44,999 Da
OMIM
611741
Type Info
Guinea Pig IgG
Immunogen
(C)TASLDPDDFDPEPSDPLGSP

Product Categories/Family for anti-ASIC 3 antibody

Antibodies; Pain and Inflammation; ASIC 3
Applications Tested/Suitable for anti-ASIC 3 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC)

Testing Data of anti-ASIC 3 antibody

Anti-ASIC 3 Polyclonal Antibody – Cat# MBS555355

Testing Data of anti-ASIC 3 antibody

Image: Detection of ASIC3 expression in normal and CF human lung tissues by immunofluorescence microscopy. Normal (top panels A-C) and CF human lung sections (bottom panels D-F) were labeled with a specific antibody against ASIC3 (green channel) and the DNA-selective Hoechst dye (blue channel). A and D, normal and CF human lung sections imaged following incubation with the mixture of anti-ASIC3 antibody and immunopeptide. Shown are normal (B) and CF (E) alveolar structures at a small magnification. ASIC3 expression was detected in both types I and II alveolar cells. Shown are normal (C) and CF (F) alveolar structures at a large magnification. Scale bars equal 10 mum in A, B, D, and E and 20 mum in C and F. These representative images were from 11 sections of four CF lungs. J. Biol. Chem., Vol. 281, Issue 48, 36960-36968, December 1, 2006
Anti-ASIC 3 Polyclonal Antibody, Testing Data – Cat# MBS555355

Other Notes

Small volumes of anti-ASIC 3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASIC 3 purchase

MBS555355 is an antibody targeting ASIC 3. Also known as ASIC3 [DRASIC], Antiserum, guinea pig. Reactive in Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for ASIC 3. It may not necessarily be applicable to this product.

NCBI GI #
9998948
NCBI GeneID
9311
NCBI Accession #
NP_064718.1
UniProt Secondary Accession #
O60263; O75906; Q59FN9; Q9UER8; Q9UHC4; B2R9V0
UniProt Related Accession #
Q9UHC3
GenBank Nucleotide #
NM_020322.3
NCBI Official Full Name
acid-sensing ion channel 3 isoform c
NCBI Official Synonym Full Names
acid sensing ion channel subunit 3
NCBI Official Symbol
ASIC3
NCBI Official Synonym Symbols
ACCN3; TNaC1; DRASIC; SLNAC1
UniProt Protein Name
Acid-sensing ion channel 3
UniProt Synonym Protein Names
Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1; hTNaC1
UniProt Gene Name
ASIC3
UniProt Synonym Gene Names
ACCN3; SLNAC1; TNAC1; ASIC3; hASIC3; hTNaC1
UniProt Entry Name
ASIC3_HUMAN
NCBI Protein Information
acid-sensing ion channel 3

UniProt Comments for ASIC 3

ASIC3: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: plasma membrane

Molecular Function: cation channel activity; sodium channel activity

Biological Process: sensory perception; sensory perception of sour taste; signal transduction; transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ASIC 3 antibody

 Reference Product  PubMed Publications
 TRPV1 antibody  >56 publications with ASIC 3 and TRPV1
 PICK1 antibody  >3 publications with ASIC 3 and PICK1
 CFTR antibody  >2 publications with ASIC 3 and CFTR
 DLG4 antibody  >1 publications with ASIC 3 and DLG4
 LIN7B antibody  >1 publications with ASIC 3 and LIN7B

Pathways associated with anti-ASIC 3 antibody

 Products by Pathway  Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-ASIC 3 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >150 publications with ASIC 3 and Pain
 Acidosis Antibodies  >70 publications with ASIC 3 and Acidosis
 Inflammation Antibodies  >54 publications with ASIC 3 and Inflammation
 Hyperalgesia Antibodies  >41 publications with ASIC 3 and Hyperalgesia
 Cardiovascular Diseases Antibodies  >22 publications with ASIC 3 and Cardiovascular Diseases
 Arthritis Antibodies  >10 publications with ASIC 3 and Arthritis
 Gastrointestinal Diseases Antibodies  >9 publications with ASIC 3 and Gastrointestinal Diseases
 Brain Diseases Antibodies  >7 publications with ASIC 3 and Brain Diseases
 Headache Antibodies  >4 publications with ASIC 3 and Headache
 Stroke Antibodies  >4 publications with ASIC 3 and Stroke

Organs/Tissues associated with anti-ASIC 3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >59 publications with ASIC 3 and Brain
 Muscle Antibodies  >57 publications with ASIC 3 and Muscle
 Blood Antibodies  >27 publications with ASIC 3 and Blood
 Skin Antibodies  >21 publications with ASIC 3 and Skin
 Eye Antibodies  >6 publications with ASIC 3 and Eye
 Lung Antibodies  >5 publications with ASIC 3 and Lung
 Embryonic Tissue Antibodies  >4 publications with ASIC 3 and Embryonic Tissue
 Ovary Antibodies  >4 publications with ASIC 3 and Ovary
 Testis Antibodies  >3 publications with ASIC 3 and Testis
 Uterus Antibodies  >1 publications with ASIC 3 and Uterus
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