Erythropoietin-Alpha Fc/Chimera (EPO-alpha) Human Recombinant Protein

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.

1. Efficacy and tolerability of intravenous continuous erythropoietin receptor activator: a 19-week, phase II, multicenter, randomized, open-label, dose-finding study with a 12-month extension phase in patients with chronic renal disease. Clin Ther 2007 Apr;29(4):626-39.2. The efficacy of preoperative administration of a single dose of recombinant human erythropoietin in pediatric cardiac surgery. Heart Surg Forum 2007;10(2):E115-9.3. Neurocognitive dysfunction post-cardiac surgery and the neuroprotective effects of erythropoietin. Can J Cardiovasc Nurs 2007;17(2):5-8; quiz 8-9, 5.4. [Pure red cell aplasia in patients treated with recombinant erythropoietin for anemia due to chronic renal disease] Rinsho Ketsueki 2007 May;48(5):391-6.5. Erythropoietin, the FDA, and oncology. N Engl J Med 2007 Jun 14;356(24):2448-51.6. Do cancer cells express functional erythropoietin receptors? N Engl J Med 2007 Jun 14;356(24):2447.

Small volumes of EPO-alpha recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS555495 is a recombinant protein targeting EPO-alpha. Also known as Recombinant Human Erythropoietin-alpha Fc/Chimera. Reactive in Human.